Skip to main content

Table 1 Statistical power in Mendelian randomization (MR) study of circulating vitamin E and cancer risk in cancer-specific GWAS

From: Association between circulating vitamin E and ten common cancers: evidence from large-scale Mendelian randomization analysis and a longitudinal cohort study

Cancer type Sample size (N = 602,435) F-statistics Minimum detectable ORa
Cases (N = 297,699) Controls (N = 304,736)
Bladder cancer 5930 5468 198.12 0.67/1.49
Breast cancer 122,977 105,974 3960.48 0.91/1.09
Colorectal cancer 24,476 23,073 823.31 0.82/1.22
Esophagus cancer 2268 1865 72.48 0.53/1.97
Lung cancer 29,266 56,450 1483.37 0.85/1.16
Oral and pharynx cancer 4950 2907 136.88 0.63/1.70
Ovarian cancer 22,406 40,941 1096.52 0.83/1.19
Pancreatic cancer 4970 3532 148.03 0.64/1.63
Prostate cancer 79,148 61,106 2426.55 0.89/1.12
Kidney cancer 1308 3420 82.77 0.44/1.81
  1. aMinimum detectable OR (per 1 SD of vitamin E) was calculated based on 80% power, 5% alpha level, and 1.7% of vitamin E variance (R2) explained by 3 SNPs used in this study