Association between circulating vitamin E and ten common cancers: evidence from large-scale Mendelian randomization analysis and a longitudinal cohort study

Xin, Junyi; Jiang, Xia; Ben, Shuai; Yuan, Qianyu; Su, Li; Zhang, Zhengdong; Christiani, David C.; Du, Mulong; Wang, Meilin

doi:10.1186/s12916-022-02366-5

Table 3 Genetic risk score (GRS) analysis for the associations of vitamin E with cancer risk in the UK Biobank cohort

From: Association between circulating vitamin E and ten common cancers: evidence from large-scale Mendelian randomization analysis and a longitudinal cohort study

Cancer type	Cases	Method^a	HR^b	95% CI^b	P^b	Corrected P^c
Bladder cancer	526	Circulating vitamin E-based GRS	0.86	0.05, 14.64	0.918	0.983
		One-sample weighted GRS	0.70	0.28, 1.75	0.444	0.989
		One-sample unweighted GRS	0.75	0.29, 1.93	0.551	0.988
Breast cancer	4350	Circulating vitamin E-based GRS	2.30	0.86, 6.14	0.096	0.337
		One-sample weighted GRS	1.06	0.82, 1.36	0.674	0.989
		One-sample unweighted GRS	1.06	0.82, 1.38	0.664	0.988
Colorectal cancer	2621	Circulating vitamin E-based GRS	0.43	0.12, 1.54	0.194	0.400
		One-sample weighted GRS	1.19	0.79, 1.80	0.404	0.989
		One-sample unweighted GRS	1.22	0.80, 1.87	0.348	0.988
Esophagus cancer	460	Circulating vitamin E-based GRS	14.06	0.72, 275.16	0.082	0.337
		One-sample weighted GRS	1.01	0.38, 2.69	0.989	0.989
		One-sample unweighted GRS	0.99	0.36, 2.72	0.988	0.988
Lung cancer	1700	Circulating vitamin E-based GRS	0.79	0.16, 3.89	0.772	0.983
		One-sample weighted GRS	1.17	0.70, 1.96	0.542	0.989
		One-sample unweighted GRS	1.16	0.69, 1.97	0.573	0.988
Oral and pharynx cancer	458	Circulating vitamin E-based GRS	1.03	0.05, 21.74	0.983	0.983
		One-sample weighted GRS	0.93	0.35, 2.50	0.891	0.989
		One-sample unweighted GRS	0.87	0.32, 2.39	0.792	0.988
Ovarian cancer	437	Circulating vitamin E-based GRS	2.09	0.09, 47.08	0.644	0.983
		One-sample weighted GRS	0.87	0.39, 1.92	0.724	0.989
		One-sample unweighted GRS	0.86	0.38, 1.96	0.722	0.988
Pancreatic cancer	506	Circulating vitamin E-based GRS	1.08	0.06, 20.08	0.960	0.983
		One-sample weighted GRS	0.94	0.37, 2.41	0.898	0.989
		One-sample unweighted GRS	0.96	0.37, 2.52	0.934	0.988
Prostate cancer	4882	Circulating vitamin E-based GRS	0.54	0.21, 1.39	0.200	0.400
		One-sample weighted GRS	0.93	0.72, 1.19	0.572	0.989
		One-sample unweighted GRS	0.97	0.75, 1.26	0.840	0.988
Kidney cancer	649	Circulating vitamin E-based GRS	0.11	0.01, 1.54	0.101	0.337
		One-sample weighted GRS	0.68	0.30, 1.57	0.370	0.989
		One-sample unweighted GRS	0.73	0.31, 1.70	0.466	0.988

^aCirculating vitamin E-based GRS, derived from three circulating vitamin E-SNPs; one-sample weighted and unweighted GRS, derived from dietary vitamin E-SNPs (P-value ≤ 5×10^-5)
^bAdjusted for sex, age, study centers, body mass index (BMI), smoking status, drinking status, and first ten principal components when appropriate
^cThe corrected P-value was calculated with false discovery rate (FDR) method

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ISSN: 1741-7015

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