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Table 3 Genetic risk score (GRS) analysis for the associations of vitamin E with cancer risk in the UK Biobank cohort

From: Association between circulating vitamin E and ten common cancers: evidence from large-scale Mendelian randomization analysis and a longitudinal cohort study

Cancer type Cases Methoda HRb 95% CIb Pb Corrected Pc
Bladder cancer 526 Circulating vitamin E-based GRS 0.86 0.05, 14.64 0.918 0.983
One-sample weighted GRS 0.70 0.28, 1.75 0.444 0.989
One-sample unweighted GRS 0.75 0.29, 1.93 0.551 0.988
Breast cancer 4350 Circulating vitamin E-based GRS 2.30 0.86, 6.14 0.096 0.337
One-sample weighted GRS 1.06 0.82, 1.36 0.674 0.989
One-sample unweighted GRS 1.06 0.82, 1.38 0.664 0.988
Colorectal cancer 2621 Circulating vitamin E-based GRS 0.43 0.12, 1.54 0.194 0.400
One-sample weighted GRS 1.19 0.79, 1.80 0.404 0.989
One-sample unweighted GRS 1.22 0.80, 1.87 0.348 0.988
Esophagus cancer 460 Circulating vitamin E-based GRS 14.06 0.72, 275.16 0.082 0.337
One-sample weighted GRS 1.01 0.38, 2.69 0.989 0.989
One-sample unweighted GRS 0.99 0.36, 2.72 0.988 0.988
Lung cancer 1700 Circulating vitamin E-based GRS 0.79 0.16, 3.89 0.772 0.983
One-sample weighted GRS 1.17 0.70, 1.96 0.542 0.989
One-sample unweighted GRS 1.16 0.69, 1.97 0.573 0.988
Oral and pharynx cancer 458 Circulating vitamin E-based GRS 1.03 0.05, 21.74 0.983 0.983
One-sample weighted GRS 0.93 0.35, 2.50 0.891 0.989
One-sample unweighted GRS 0.87 0.32, 2.39 0.792 0.988
Ovarian cancer 437 Circulating vitamin E-based GRS 2.09 0.09, 47.08 0.644 0.983
One-sample weighted GRS 0.87 0.39, 1.92 0.724 0.989
One-sample unweighted GRS 0.86 0.38, 1.96 0.722 0.988
Pancreatic cancer 506 Circulating vitamin E-based GRS 1.08 0.06, 20.08 0.960 0.983
One-sample weighted GRS 0.94 0.37, 2.41 0.898 0.989
One-sample unweighted GRS 0.96 0.37, 2.52 0.934 0.988
Prostate cancer 4882 Circulating vitamin E-based GRS 0.54 0.21, 1.39 0.200 0.400
One-sample weighted GRS 0.93 0.72, 1.19 0.572 0.989
One-sample unweighted GRS 0.97 0.75, 1.26 0.840 0.988
Kidney cancer 649 Circulating vitamin E-based GRS 0.11 0.01, 1.54 0.101 0.337
One-sample weighted GRS 0.68 0.30, 1.57 0.370 0.989
One-sample unweighted GRS 0.73 0.31, 1.70 0.466 0.988
  1. aCirculating vitamin E-based GRS, derived from three circulating vitamin E-SNPs; one-sample weighted and unweighted GRS, derived from dietary vitamin E-SNPs (P-value ≤ 5×10-5)
  2. bAdjusted for sex, age, study centers, body mass index (BMI), smoking status, drinking status, and first ten principal components when appropriate
  3. cThe corrected P-value was calculated with false discovery rate (FDR) method
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BMC Medicine

ISSN: 1741-7015

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