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Fig. 6 | BMC Medicine

Fig. 6

From: Sustained correction of hippocampal neurogenic and cognitive deficits after a brief treatment by Nutlin-3 in a mouse model of fragile X syndrome

Fig. 6

Top TFs ranked by TF enrichment analysis were associated to ECM and stem cell fate. a Transcription factor target enrichment analysis of differentially expressed genes in Fmr1 KO treated with Nutlin-3 vs vehicle using average integrated ranks across all libraries through ChEA3 (n = 3). FET, Fisher’s exact test. Orange bars indicate TFs associated with ECM. Green bars indicate TFs associated with stem cell fate. Orange and green patterned bars indicate TFs associated to both ECM and stem cell function, respectively. b top TF network generated by Chea3 using the average integrated ranks across all libraries

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