Genetic susceptibility, screen-based sedentary activities and incidence of coronary heart disease

Table 2 Associations of TV viewing and computer use with incident coronary heart disease (CHD).

Comparisons	Number of participants	Number of cases	Crude incident rate per 100,000-person years	Hazard ratio (95% confidence interval)
Comparisons	373,026	9185	195.3	Model 1^a	Model 2^b	Model 3^c
Categories of TV viewing
≥4h/day (reference)	106,510	3501	261.8	1.00 (reference)	1.00 (reference)	1.00 (reference)
2–3h/day	191,555	4413	182.5	0.81 (0.78–0.85)	0.94 (0.89–0.98)	0.94 (0.90–0.99)
≤1h/day	74,961	1217	133.9	0.66 (0.62–0.70)	0.83 (0.78–0.89)	0.84 (0.79–0.90)
Categories of computer use
≥4h/day (Reference)	19,253	515	213.6	1.00 (Reference)	1.00 (Reference)	1.00 (Reference)
2–3h/day	60,596	1719	226.9	0.92 (0.83–1.02)	1.01 (0.91–1.11)	1.00 (0.91–1.10)
≤1h/day	293,177	6951	187.6	0.78 (0.71–0.85)	1.00 (0.92–1.10)	0.99 (0.91–1.09)

^aModel 1: Adjusted for no confounders
^bModel 2: Adjusted for all confounders in Model 1 plus sex, body mass index (weight in kilograms/height in meters squared), smoking status (never, previous, current), employment (unemployed, employed), Townsend Deprivation Index (a numerical deprivation score generated based on employment, car ownership, home ownership and household overcrowding according to postcode of participants’ home address), alcohol consumption (never, previous, currently <3 times/week, currently ≥3 times/week), salt-adding behaviour (never/rarely, sometimes, usually, always), oily fish consumption (never, <once/week, once/week, >once/week), coffee intake (cups/day), fruit and vegetable intake (a composite score generated based on intake of fresh/dried fruit and intake of raw/cooked vegetable ranging from 0 to 4), processed/red meat intake (days/week), hypertension medication use, cholesterol-lowering medication use, glucose-lowering medication use, sleep (≤5, 6, 7, 8 and ≥9h/day) and moderate-to-vigorous physical activity (minutes/day)
^cModel 3: Adjusted for all confounders in Model 2 plus the polygenic risk score, genotype array type and first ten principal components of genetic ancestry

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