Table 2 Associations of handgrip strength with the risk of cardiometabolic multimorbidity
| Â | Unadjusted model | Adjusted model | ||
|---|---|---|---|---|
HR (95% CI) | P | HR (95% CI) | P | |
Participants without any cardiometabolic disease at baseline (Participants=441,868 / CM cases=4,701) | ||||
Q4 (highest) | 1 (reference) | Â | 1 (reference) | Â |
Q3 | 1.32 (1.21–1.45) |  < 0.0001 | 1.08 (0.99–1.19) | 0.0943 |
Q2 | 1.70 (1.56–1.86) |  < 0.0001 | 1.23 (1.13–1.34) |  < 0.0001 |
Q1 (lowest) | 2.41 (2.22–2.62) |  < 0.0001 | 1.46 (1.34–1.60) |  < 0.0001 |
Continuous variablea | 1.21 (1.18–1.24) |  < 0.0001 | 1.17 (1.14–1.21) |  < 0.0001 |
Participants with type 2 diabetes at baseline (Participants=18,224 / CM cases=3,505) | ||||
Q4 (highest) | 1 (reference) | Â | 1 (reference) | Â |
Q3 | 1.06 (0.96–1.17) | 0.2774 | 1.01 (0.91–1.11) | 0.8936 |
Q2 | 1.38 (1.26–1.51) |  < 0.0001 | 1.15 (1.05–1.26) | 0.0039 |
Q1 (lowest) | 1.71 (1.56–1.88) |  < 0.0001 | 1.35 (1.23–1.49) |  < 0.0001 |
Continuous variable | 1.14 (1.10–1.17) |  < 0.0001 | 1.13 (1.09–1.17) |  < 0.0001 |
Participants with stroke at baseline (Participants=6,092 / CM cases=1,258) | ||||
Q4 (highest) | 1 (reference) | Â | 1 (reference) | Â |
Q3 | 1.02 (0.87–1.20) | 0.7725 | 0.97 (0.82–1.13) | 0.6687 |
Q2 | 1.24 (1.06–1.45) | 0.0068 | 1.06 (0.90–1.24) | 0.4766 |
Q1 (lowest) | 1.53 (1.30–1.80) |  < 0.0001 | 1.23 (1.04–1.46) | 0.0159 |
Continuous variable | 1.08 (1.02–1.13) |  < 0.0001 | 1.10 (1.03–1.16) | 0.0021 |
Participants with CHD at baseline (Participants=20,996 / CM cases=3,301) | ||||
Q4 (highest) | 1 (reference) | Â | 1 (reference) | Â |
Q3 | 1.16 (1.05–1.28) | 0.0025 | 1.14 (1.03–1.25) | 0.0110 |
Q2 | 1.24 (1.13–1.37) |  < 0.0001 | 1.15 (1.05–1.27) | 0.0045 |
Q1 (lowest) | 1.42 (1.29–1.57) |  < 0.0001 | 1.23 (1.11–1.36) |  < 0.0001 |
Continuous variable | 1.08 (1.04–1.11) |  < 0.0001 | 1.09 (1.05–1.13) |  < 0.0001 |