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Table 2 Results of univariate meta-regression analyses of demographic and clinical risk factors for FSIQ impairment

From: Intelligence outcome of pediatric intensive care unit survivors: a systematic meta-analysis and meta-regression

Risk factors

k

Beta

95% CI

R2 (%)

Range studied

Year of PICU admission

104

-0.014 ***

-0.021, -0.007

21

1972–2016

Sex (% boys)

107

0.007 *

0.001, 0.014

5

27.0–80.8

Gestational age (weeks)

49

-0.069

-0.188, 0.051

0

35.7–40.6

Age at PICU admission (months)

107

0.000

-0.002, 0.002

1

0.0–159.6

Mechanical ventilation (days)

21

-0.011

-0.030, 0.007

0

0.0–41.5

PICU stay (days)

36

-0.014 *

-0.027, -0.002

2

0.3–35.4

Resuscitation (%)

22

-0.005

-0.011, 0.001

2

0.0–100

ECMO (%)

28

-0.002

-0.005, 0.002

0

0.0–100

Rate of survivors (%)

56

0.014 ***

0.006, 0.022

11

38.2–100

Age at follow-up (months)

117

0.000

-0.001, 0.001

0

30.1–307.2

Time to follow-up (months)

110

-0.000

-0.002, 0.001

0

0.1–231.6

Study quality

129

-0.109 *

-0.198, -0.020

7

3–7

  1. k = number of samples; ECMO = extra-corporeal membrane oxygenation; PICU = pediatric intensive care unit; Study quality was assessed by the Newcastle Ottawa Scale for cohort studies, revised to a maximum of 7 points. Unstandardized Beta’s are reported. *p < .05. **p < .01. ***p < .001