Fig. 7

Effect of intraperitoneal administration of EZH2 inhibitor on placental H3K27me3, ADAM12, Hsd11b2 abundance, and maternal blood ADAM12-S level in the mouse. A EPZ administration (8 mg/kg BW) decreased the abundance of placental H3K27me3 (control group, n = 24; EPZ group, n = 24). Top panel is the representative immunoblot. B, C EPZ administration (8 mg/kg BW) increased the abundance of placental Adam12s and Hsd11b2 mRNA (control group, n = 63; EPZ group, n = 53). D EPZ administration (8 mg/kg BW) increased ADAM12-S level in maternal blood (control group, n = 7; EPZ group, n = 6). Data are means ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001 vs control group