Fig. 4

Overview of the validation study. A The ratio between male and female individuals with a spinal cord injury. Depending on the year, the ratio of male and female spinal cord injury individuals changed between 3:1 and 4:1. B Distribution of age at injury. Throughout the clinical trial period, there was no change in distribution of age at injury. Important to note, the average age at injury of the Sygen clinical trial cohort, independent of sex, was significantly lower compared to the EMSCI cohort. C Baseline injury severity and D injury level: The proportions of injury characteristics remained constant between 1992 and 1997. E Motor and F sensory recovery stratified by AIS grade and plegia (i.e., paraplegia or tetraplegia). The solid lines represent the fitted models and the shaded areas the standard error