Variables | Total (N=138,110) | NSCLC (N=2641) | Non-NSCLC (N=135,469) | HR (95% CI) | P-value* |
---|---|---|---|---|---|
Age (years)a, Mean ± SD | 62.56 ± 5.34 | 64.34 ± 5.20 | 62.53 ± 5.34 | 1.06 (1.05, 1.07) | < 2×10−16 |
Sex, N (%) | |||||
 Male | 69,713 (50.48) | 1646 (62.32) | 68,067 (50.25) | Reference |  |
 Female | 68,397 (49.52) | 995 (37.68) | 67,402 (49.75) | 0.61 (0.56, 0.66) | < 2×10−16 |
Race, N (%) | |||||
 White, non-Hispanic | 122,404 (88.63) | 2343 (88.72) | 120,061 (88.63) | Reference |  |
 Black, non-Hispanic | 6868 (4.97) | 184 (6.97) | 6684 (4.93) | 1.58 (1.36, 1.84) | 2.32×10−9 |
 Hispanic | 2552 (1.85) | 32 (1.20) | 2520 (1.86) | 0.70 (0.50, 1.00) | 0.049 |
 Asian | 5133 (3.72) | 63 (2.39) | 5070 (3.74) | 0.62 (0.48, 0.80) | 2.09×10−4 |
 Other | 1153 (0.83) | 19 (0.72) | 1134 (0.84) | 0.91 (0.58, 1.43) | 0.673 |
Family history of lung cancer, N (%) | |||||
 Absent | 119,147 (86.88) | 2050 (78.21) | 117,097 (87.05) | Reference |  |
 Present | 14,376 (10.48) | 447 (17.05) | 13,929 (10.35) | 1.83 (1.66, 2.03) | < 2×10−16 |
 Missing | 3616 (2.64) | 124 (4.73) | 4443 (2.60) |  |  |
Education, N (%) | |||||
 HS or less | 41,506 (30.05) | 1007 (38.13) | 40,499 (29.90) | Reference |  |
 Post HS or some college | 47,376 (34.30) | 986 (37.33) | 46,390 (34.24) | 0.90 (0.80, 1.01) | 0.065 |
 College graduate or degree | 48,968 (35.46) | 645 (24.42) | 48,323 (35.67) | 0.63 (0.58, 0.69) | < 2×10−16 |
 Missing | 260 (0.19) | 3 (0.12) | 257 (0.19) |  |  |
BMI at age 20 (kg/m2), Mean ± SD | 22.10 ± 3.01 | 22.11 ± 2.99 | 22.10 ± 3.01 | 1.00 (0.99, 1.02) | 0.520 |
BMI at age 50 (kg/m2), Mean ± SD | 25.85 ± 4.17 | 25.16 ± 3.70 | 25.87 ± 4.18 | 0.96 (0.95, 0.97) | 5.66×10−15 |
BMI at baseline (kg/m2), Mean ± SD | 27.30 ± 4.75 | 26.49 ± 4.43 | 27.32 ± 4.75 | 0.96 (0.95, 0.97) | 3.65×10−16 |
Smoking status, N (%) | |||||
 Never | 63,945 (46.30) | 217 (8.22) | 63,728 (47.04) | Reference |  |
 Former | 59,685 (43.22) | 1365 (51.68) | 58,320 (43.06) | 6.94 (6.01, 8.01) | < 2×10−16 |
 Current | 14,464 (10.47) | 1059 (40.10) | 13,405 (9.89) | 24.22 (20.93, 28.03) | < 2×10−16 |
 Missing | 16 (0.01) | 0 | 16 (0.01) |  |  |
Personal history of diabetes, N (%) | |||||
 Absent | 127,024 (91.97) | 2398 (90.80) | 124,626 (92.00) | Reference |  |
 Present | 10,426 (7.55) | 221 (8.37) | 10,205 (7.53) | 1.25 (1.09, 1.44) | 0.001 |
 Missing | 660 (0.48) | 22 (0.83) | 638 (0.47) |  |  |
Current marital status, N (%) | |||||
 Married or living with someone | 105,276 (76.23) | 1890 (70.96) | 103,386 (76.32) | Reference |  |
 Divorced, separated, or widowed | 28,030 (20.30) | 677 (26.35) | 27,353 (20.19) | 1.41 (1.30, 1.54) | 1.08×10−14 |
 Single, never married | 4580 (3.32) | 71 (2.56) | 4509 (3.33) | 0.91 (0.71, 1.15) | 0.409 |
 Missing | 224 (0.15) | 3 (0.13) | 221 (0.16) |  |  |
Hormone replacement therapy (in female), N (%) | |||||
 Never | 22,083 (32.31) | 389 (39.10) | 21,694 (32.19) | Reference |  |
 Current | 34,779 (50.82) | 411 (41.31) | 34,368 (50.99) | 0.67 (0.58, 0.77) | 1.09×10−8 |
 Former | 11,120 (16.26) | 187 (18.79) | 10,933 (16.22) | 0.95 (0.80, 1.14) | 0.600 |
 Missing | 353 (0.61) | 8 (0.80) | 345 (0.60) |  |  |
Study centre, N (%) | |||||
 1 = University of Colorado | 11,852 (8.58) | 178 (6.74) | 11,674 (8.62) | Reference |  |
 2 = Georgetown University | 6294 (4.56) | 111 (4.20) | 6183 (4.56) | 1.13 (0.89, 1.43) | 0.310 |
 3 = Pacific Health Research and Education Institute (Honolulu) | 9362 (6.78) | 176 (6.66) | 9186 (6.78) | 1.24 (1.01, 1.53) | 0.045 |
 4 = Henry Ford Health System | 21,887 (15.85) | 442 (16.74) | 21,445 (15.83) | 1.47 (1.24, 1.75) | 1.35×10−5 |
 5 = University of Minnesota | 24,613 (17.82) | 510 (19.31) | 24,103 (17.79) | 1.36 (1.15, 1.62) | 3.83×10−4 |
 6 = Washington University in St Louis | 13,763 (9.96) | 310 (11.74) | 13,453 (9.93) | 1.54 (1.28, 1.85) | 4.60×10−6 |
 8 = University of Pittsburgh | 16,021 (11.60) | 350 (13.25) | 15,671 (11.57) | 1.48 (1.23, 1.77) | 2.31×10−5 |
 9 = University of Utah | 13,449 (9.74) | 175 (6.63) | 13,274 (9.80) | 0.87 (0.70, 1.07) | 0.180 |
 10 = Marshfield Clinic Research Foundation | 15,153 (10.97) | 289 (10.94) | 14,864 (10.97) | 1.25 (1.04, 1.51) | 0.017 |
 11 = University of Alabama at Birmingham | 5716 (4.14) | 100 (3.79) | 5616 (4.15) | 1.44 (1.13, 1.84) | 0.004 |