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Table 1 Characteristics of the study subjects

From: Associations of genetic risk, BMI trajectories, and the risk of non-small cell lung cancer: a population-based cohort study

Variables

Total (N=138,110)

NSCLC (N=2641)

Non-NSCLC (N=135,469)

HR (95% CI)

P-value*

Age (years)a, Mean ± SD

62.56 ± 5.34

64.34 ± 5.20

62.53 ± 5.34

1.06 (1.05, 1.07)

< 2×10−16

Sex, N (%)

 Male

69,713 (50.48)

1646 (62.32)

68,067 (50.25)

Reference

 

 Female

68,397 (49.52)

995 (37.68)

67,402 (49.75)

0.61 (0.56, 0.66)

< 2×10−16

Race, N (%)

 White, non-Hispanic

122,404 (88.63)

2343 (88.72)

120,061 (88.63)

Reference

 

 Black, non-Hispanic

6868 (4.97)

184 (6.97)

6684 (4.93)

1.58 (1.36, 1.84)

2.32×10−9

 Hispanic

2552 (1.85)

32 (1.20)

2520 (1.86)

0.70 (0.50, 1.00)

0.049

 Asian

5133 (3.72)

63 (2.39)

5070 (3.74)

0.62 (0.48, 0.80)

2.09×10−4

 Other

1153 (0.83)

19 (0.72)

1134 (0.84)

0.91 (0.58, 1.43)

0.673

Family history of lung cancer, N (%)

 Absent

119,147 (86.88)

2050 (78.21)

117,097 (87.05)

Reference

 

 Present

14,376 (10.48)

447 (17.05)

13,929 (10.35)

1.83 (1.66, 2.03)

< 2×10−16

 Missing

3616 (2.64)

124 (4.73)

4443 (2.60)

  

Education, N (%)

 HS or less

41,506 (30.05)

1007 (38.13)

40,499 (29.90)

Reference

 

 Post HS or some college

47,376 (34.30)

986 (37.33)

46,390 (34.24)

0.90 (0.80, 1.01)

0.065

 College graduate or degree

48,968 (35.46)

645 (24.42)

48,323 (35.67)

0.63 (0.58, 0.69)

< 2×10−16

 Missing

260 (0.19)

3 (0.12)

257 (0.19)

  

BMI at age 20 (kg/m2), Mean ± SD

22.10 ± 3.01

22.11 ± 2.99

22.10 ± 3.01

1.00 (0.99, 1.02)

0.520

BMI at age 50 (kg/m2), Mean ± SD

25.85 ± 4.17

25.16 ± 3.70

25.87 ± 4.18

0.96 (0.95, 0.97)

5.66×10−15

BMI at baseline (kg/m2), Mean ± SD

27.30 ± 4.75

26.49 ± 4.43

27.32 ± 4.75

0.96 (0.95, 0.97)

3.65×10−16

Smoking status, N (%)

 Never

63,945 (46.30)

217 (8.22)

63,728 (47.04)

Reference

 

 Former

59,685 (43.22)

1365 (51.68)

58,320 (43.06)

6.94 (6.01, 8.01)

< 2×10−16

 Current

14,464 (10.47)

1059 (40.10)

13,405 (9.89)

24.22 (20.93, 28.03)

< 2×10−16

 Missing

16 (0.01)

0

16 (0.01)

  

Personal history of diabetes, N (%)

 Absent

127,024 (91.97)

2398 (90.80)

124,626 (92.00)

Reference

 

 Present

10,426 (7.55)

221 (8.37)

10,205 (7.53)

1.25 (1.09, 1.44)

0.001

 Missing

660 (0.48)

22 (0.83)

638 (0.47)

  

Current marital status, N (%)

 Married or living with someone

105,276 (76.23)

1890 (70.96)

103,386 (76.32)

Reference

 

 Divorced, separated, or widowed

28,030 (20.30)

677 (26.35)

27,353 (20.19)

1.41 (1.30, 1.54)

1.08×10−14

 Single, never married

4580 (3.32)

71 (2.56)

4509 (3.33)

0.91 (0.71, 1.15)

0.409

 Missing

224 (0.15)

3 (0.13)

221 (0.16)

  

Hormone replacement therapy (in female), N (%)

 Never

22,083 (32.31)

389 (39.10)

21,694 (32.19)

Reference

 

 Current

34,779 (50.82)

411 (41.31)

34,368 (50.99)

0.67 (0.58, 0.77)

1.09×10−8

 Former

11,120 (16.26)

187 (18.79)

10,933 (16.22)

0.95 (0.80, 1.14)

0.600

 Missing

353 (0.61)

8 (0.80)

345 (0.60)

  

Study centre, N (%)

 1 = University of Colorado

11,852 (8.58)

178 (6.74)

11,674 (8.62)

Reference

 

 2 = Georgetown University

6294 (4.56)

111 (4.20)

6183 (4.56)

1.13 (0.89, 1.43)

0.310

 3 = Pacific Health Research and Education Institute (Honolulu)

9362 (6.78)

176 (6.66)

9186 (6.78)

1.24 (1.01, 1.53)

0.045

 4 = Henry Ford Health System

21,887 (15.85)

442 (16.74)

21,445 (15.83)

1.47 (1.24, 1.75)

1.35×10−5

 5 = University of Minnesota

24,613 (17.82)

510 (19.31)

24,103 (17.79)

1.36 (1.15, 1.62)

3.83×10−4

 6 = Washington University in St Louis

13,763 (9.96)

310 (11.74)

13,453 (9.93)

1.54 (1.28, 1.85)

4.60×10−6

 8 = University of Pittsburgh

16,021 (11.60)

350 (13.25)

15,671 (11.57)

1.48 (1.23, 1.77)

2.31×10−5

 9 = University of Utah

13,449 (9.74)

175 (6.63)

13,274 (9.80)

0.87 (0.70, 1.07)

0.180

 10 = Marshfield Clinic Research Foundation

15,153 (10.97)

289 (10.94)

14,864 (10.97)

1.25 (1.04, 1.51)

0.017

 11 = University of Alabama at Birmingham

5716 (4.14)

100 (3.79)

5616 (4.15)

1.44 (1.13, 1.84)

0.004

  1. *Univariate cox proportional hazard regression model
  2. aAge at the time of study enrolment
  3. NSCLC non-small cell lung cancer, BMI body mass index, HR hazard ratio, CI confidence interval