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Table 2 Results from aggregate segmented linear regression analyses estimating the absolute immediate, gradual, and overall (at 12 months post-intervention) effects of study interventions on receiving an average initial duration of ≥ 90 days across cardiac medications dispensed at index fill among post-myocardial infarction patients age 65 and older in Ontario, Canada from September 2015 to August 2018

From: Length of initial prescription at hospital discharge and long-term medication adherence for elderly, post-myocardial infarction patients: a population-based interrupted time series study

Parameter

Estimate, % (95% CI)

P value

Standardized prolonged discharge prescription forms plus education (2 sites, 1414 patients)

 Intercept (baseline percentage)

4.76 (− 1.28 to 10.8)

.10

 Pre-intervention slope (secular trend, per month)

0.04 (− 0.40 to 0.47)

.83

 Change in level post-intervention (immediate effect)

4.02 (− 5.15 to 13.2)

.35

 Change in trend post-intervention (gradual effect, per month)

0.18 (− 1.06 to 1.43)

.73

 Overall effect at 12 months post-intervention (combined immediate and gradual effect)

6.19 (− 7.51 to 19.9)

.30

Education only (4 sites, 926 patients)

 Intercept (baseline percentage)

6.16 (2.25 to 10.1)

.006

 Pre-intervention slope (secular trend, per month)

0.10 (− 0.19 to 0.39)

.47

 Change in level post-intervention (immediate effect)

3.24 (− 3.89 to 10.4)

.34

 Change in trend post-intervention (gradual effect, per month)

− 0.48 (− 1.35 to 0.39)

.25

 Overall effect at 12 months post-intervention (combined immediate and gradual effect)

− 2.55 (− 11.5 to 6.38)

.54

Control group (143 sites, 18556 patients)

 Intercept (baseline percentage)

7.40 (6.63 to 8.17)

<.001

 Pre-intervention slope (secular trend, per month)

− 0.02 (− 0.07 to 0.04)

.57

 Change in level post-intervention (immediate effect)

− 0.10 (− 1.52 to 1.31)

.88

 Change in trend post-intervention (gradual effect, per month)

− 0.01 (− 0.18 to 0.16)

.89

 Overall effect at 12 months post-intervention (combined immediate and gradual effect)

− 0.23 (− 2.00 to 1.54)

.78

  1. CI confidence interval. All results based on group-specific, aggregate segmented linear regression models, which accounted for serial correlation in monthly time series data through first-order autoregressive (i.e., AR(1)) errors. AR(1) parameter estimates for each group-specific model were 0.22, − 0.07, and − 0.07, respectively. Model parameters were estimated using restricted maximum likelihood estimation with the Satterthwaite adjustment for computing denominator degrees of freedom. Model MSE values were 23.4, 22.3, and 0.88, respectively
  2. Index fill defined as a patient’s first prescription fill within 7 days from hospital discharge, at which point ≥ 1 prescriptions were filled for a statin, beta blocker, angiotensin system inhibitor, and/or secondary antiplatelet