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Fig. 4 | BMC Medicine

Fig. 4

From: Biological aging mediates the associations between urinary metals and osteoarthritis among U.S. adults

Fig. 4

Estimated proportion of the association between urinary mixed metals and OA mediated by biological age (A), phenotypic age (B), and telomere length (C) and serially mediated by telomere length-biological age path (D) and telomere length-phenotypic age path (E). Models were adjusted for sex, age, race/ethnicity, education, family income-to-poverty ratio, marital status, body mass index, physical activity, drinking alcohol status, and serum cotinine. IE, the estimate of the indirect effect; DE, the estimate of the direct effect; Proportion of mediation = IE/DE + IE

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