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Fig. 1 | BMC Medicine

Fig. 1

From: Pinpointing novel risk loci for Lewy body dementia and the shared genetic etiology with Alzheimer’s disease and Parkinson’s disease: a large-scale multi-trait association analysis

Fig. 1

Overall study design. Pairwise genome-wide genetic correlation analysis among LBD, AD, and PD was first performed by linkage disequilibrium score regression (LDSC), followed by multi-trait meta-analysis of LBD, AD, and PD GWASs using MTAG. Based on the MTAGLBD results, SNP-level analysis and gene-level analysis were further implemented to investigate the genetic basis of LBD and shared genetics underlying LBD, AD, and PD. GWAS, genome-wide association study; MTAG, multi-trait analysis of genome-wide association studies; LBD, Lewy body dementia; AD, Alzheimer’s disease; PD, Parkinson’s disease

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BMC Medicine

ISSN: 1741-7015

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