Intention to treat | SBP < 110 mmHg | 110 ≤ SBP < 120 mmHg | 120 ≤ SBP < 130 mmHg | SBP ≥ 130 mmHg | ||||||
---|---|---|---|---|---|---|---|---|---|---|
Intensive (n = 4579) | Standard (n = 4579) | Intensive (n = 152) | Standard (n = 152) | Intensive (n = 2071) | Standard (n = 2071) | Intensive (n = 1619) | Standard (n = 1619) | Intensive (n = 636) | Standard (n = 636) | |
Demographics | ||||||||||
Age, years | 67.88 ± 9.37 | 67.84 ± 9.43 | 64.84 ± 9.52 | 65.53 ± 8.83 | 66.47 ± 8.89 | 66.42 ± 9.16 | 68.70 ± 9.21 | 68.97 ± 9.32 | 71.43 ± 9.90 | 71.95 ± 9.92 |
Female | 1643 (35.88) | 1603 (34.99) | 58 (38.16) | 62 (40.79) | 733 (35.39) | 762 (36.79) | 562 (34.71) | 553 (34.16) | 261 (41.04) | 247 (38.84) |
Race | ||||||||||
Black | 1346 (29.40) | 1389 (30.32) | 49 (32.24) | 56 (36.84) | 570 (27.52) | 560 (27.04) | 480 (29.65) | 461 (28.47) | 215 (33.81) | 201 (31.60) |
White | 2645 (57.76) | 2649 (57.83) | 76 (50.00) | 65 (42.76) | 1186 (57.32) | 1213 (58.57) | 968 (59.79) | 968 (59.79) | 353 (55.50) | 370 (58.18) |
Hispanic | 493 (10.77) | 473 (10.32) | 25 (16.45) | 28 (18.42) | 527 (12.72) | 256 (12.36) | 143 (8.83) | 158 (9.76) | 48 (7.55) | 43 (6.76) |
Others | 95 (2.07) | 70 (1.53) | 2 (1.34) | 3 (1.97) | 85 (2.05) | 42 (2.03) | 28 (1.73) | 32 (1.98) | 20 (3.14) | 22 (3.46) |
Medical history | ||||||||||
Clinical CVD | 755 (16.49) | 758 (16.55) | 30 (19.45) | 30 (19.45) | 316 (15.26) | 289 (13.95) | 272 (16.80) | 293 (18.10) | 120 (18.87) | 120 (18.87) |
CKD | 1293 (28.24) | 1287 (28.09) | 35 (23.03) | 32 (21.05) | 504 (24.34) | 487 (23.52) | 474 (29.28) | 470 (29.03) | 260 (40.88) | 243 (38.21) |
Dyslipidemia | 1941 (42.39) | 2034 (44.40) | 72 (47.37) | 78 (51.32) | 884 (42.68) | 891 (43.02) | 667 (41.20) | 669 (41.32) | 278 (43.71) | 289 (45.44) |
Hypertension treatment | 4160 (90.85) | 4143 (90.44) | 140 (92.11) | 145 (95.39) | 1853 (89.47) | 1861 (89.86) | 1473 (90.98) | 1483 (91.60) | 603 (94.81) | 600 (94.34) |
Aspirin treatment | 2361 (51.65) | 2304 (50.69) | 68 (44.74) | 64 (42.11) | 1056 (50.99) | 1047 (50.56) | 883 (54.54) | 939 (58.00) | 313 (49.21) | 310 (48.74) |
Current smoking | 629 (13.74) | 590 (12.90) | 35 (23.03) | 43 (28.29) | 284 (13.71) | 270 (13.04) | 199 (12.29) | 198 (12.23) | 87 (13.68) | 95 (14.94) |
Current drinking | 1632 (35.77) | 1607 (35.20) | 55 (36.18) | 46 (30.29) | 733 (35.39) | 753 (36.36) | 561 (34.65) | 537 (33.17) | 253 (39.78) | 257 (40.41) |
Biometric and laboratory data | ||||||||||
10-year risk for CVD, % | 24.78 ± 12.59 | 24.78 ± 12.44 | 21.25 ± 11.45 | 22.42 ± 11.81 | 22.91 ± 11.76 | 22.74 ± 11.66 | 25.73 ± 12.42 | 25.70 ± 12.17 | 28.38 ± 13.96 | 29.96 ± 13.20 |
BMI, kg/m2 | 29.87 ± 5.68 | 29.74 ± 5.59 | 31.90 ± 6.31 | 32.03 ± 7.23 | 30.38 ± 5.64 | 30.40 ± 5.57 | 29.50 ± 5.53 | 29.60 ± 5.50 | 28.52 ± 5.49 | 28.52 ± 5.53 |
SBP, mmHg | 139.60 ± 15.74 | 139.63 ± 15.38 | 132.63 ± 17.71 | 134.01 ± 13.31 | 136.85 ± 14.48 | 136.88 ± 14.66 | 141.28 ± 15.67 | 140.25 ± 15.59 | 146.33 ± 16.44 | 146.84 ± 16.60 |
DBP, mmHg | 78.24 ± 11.89 | 78.07 ± 11.93 | 78.78 ± 12.81 | 78.69 ± 11.14 | 78.80 ± 11.05 | 78.84 ± 11.75 | 77.90 ± 12.26 | 77.40 ± 11.77 | 76.94 ± 13.09 | 76.62 ± 12.24 |
BLU, mmol/L | 6.67 ± 2.40 | 6.72 ± 2.39 | 6.48 ± 2.22 | 6.43 ± 1.91 | 6.48 ± 2.22 | 6.49 ± 2.11 | 6.69 ± 2.35 | 6.70 ± 2.41 | 7.29 ± 3.00 | 7.13 ± 2.91 |
Chloride, mmol/L | 102.92 ± 2.90 | 102.93 ± 2.84 | 103.19 ± 3.21 | 103.11 ± 2.66 | 103.12 ± 2.73 | 103.07 ± 2.85 | 102.72 ± 2.93 | 102.75 ± 2.96 | 102.80 ± 3.20 | 102.99 ± 2.84 |
Creatinine, μmmol/L | 94.74 ± 30.38 | 95.17 ± 29.69 | 90.25 ± 27.45 | 89.58 ± 27.71 | 91.67 ± 26.91 | 91.05 ± 25.81 | 95.90 ± 30.94 | 95.30 ± 30.74 | 102.58 ± 36.99 | 100.51 ± 34.76 |
Heart rate | 66.18 ± 11.49 | 66.26 ± 11.59 | 66.60 ± 11.75 | 67.62 ± 11.34 | 66.71 ± 11.36 | 66.97 ± 11.47 | 65.81 ± 11.53 | 66.15 ± 11.25 | 64.66 ± 11.10 | 67.49 ± 21.99 |
eGFR, mL/min/1.73 m2 | 71.90 ± 20.68 | 71.69 ± 20.44 | 76.88 ± 23.75 | 76.94 ± 22.42 | 74.01 ± 20.14 | 74.00 ± 19.92 | 70.83 ± 19.99 | 71.21 ± 20.23 | 66.15 ± 21.46 | 67.49 ± 21.99 |
Glucose, mmol/L | 5.54 ± 0.77 | 5.53 ± 0.75 | 5.49 ± 0.68 | 5.42 ± 0.70 | 5.56 ± 0.77 | 5.61 ± 0.87 | 5.53 ± 0.77 | 5.55 ± 0.80 | 5.50 ± 0.78 | 5.51 ± 0.76 |
HDL-C, mmol/L | 1.37 ± 0.37 | 1.37 ± 0.38 | 1.33 ± 0.35 | 1.34 ± 0.33 | 1.34 ± 0.34 | 1.34 ± 0.35 | 1.39 ± 0.39 | 1.38 ± 0.39 | 1.44 ± 0.40 | 1.41 ± 0.35 |
LDL-C, mmol/L | 2.91 ± 0.92 | 2.90 ± 0.90 | 2.93 ± 0.89 | 2.89 ± 0.92 | 2.91 ± 0.91 | 2.93 ± 0.93 | 2.92 ± 0.93 | 2.91 ± 0.90 | 2.87 ± 0.92 | 2.92 ± 0.93 |
Potassium, mmol/L | 4.21 ± 0.44 | 4.20 ± 0.45 | 4.19 ± 0.54 | 4.20 ± 0.72 | 4.19 ± 0.42 | 4.18 ± 0.43 | 4.21 ± 0.42 | 4.21 ± 0.48 | 4.23 ± 0.48 | 4.22 ± 0.45 |
Sodium, mmol/L | 140.12 ± 2.46 | 140.15 ± 2.42 | 140.14 ± 2.53 | 140.32 ± 2.20 | 140.31 ± 2.25 | 140.26 ± 2.43 | 139.99 ± 2.57 | 139.95 ± 2.53 | 139.95 ± 2.75 | 140.17 ± 2.43 |
TC, mmol/L | 4.92 ± 1.07 | 4.91 ± 1.06 | 4.88 ± 1.05 | 4.81 ± 1.07 | 4.89 ± 1.05 | 4.91 ± 1.06 | 4.94 ± 1.07 | 4.91 ± 1.05 | 4.89 ± 1.05 | 4.93 ± 1.10 |
Triglycerides, mmol/L | 1.37 ± 0.95 | 1.40 ± 1.04 | 1.29 ± 0.55 | 1.23 ± 0.61 | 1.36 ± 0.68 | 1.37 ± 0.71 | 1.32 ± 0.68 | 1.33 ± 0.69 | 1.23 ± 0.61 | 1.27 ± 0.66 |
Post-baseline characteristics | ||||||||||
Achieved SBP, mmHg | 121.72 ± 8.78 | 135.51 ± 7.45 | 107.05 ± 2.65 | 134.20 ± 8.42 | 116.09 ± 2.54 | 134.95 ± 7.41 | 123.89 ± 2.72 | 136.07 ± 7.19 | 137.42 ± 8.37 | 138.09 ± 8.20 |
Achieved DBP, mmHg | 67.98 ± 8.43 | 75.11 ± 9.17 | 64.42 ± 7.70 | 77.65 ± 9.25 | 67.01 ± 7.08 | 76.25 ± 8.89 | 68.14 ± 8.42 | 74.65 ± 8.97 | 71.84 ± 9.86 | 71.48 ± 11.18 |