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Table 1 Characteristics of patients in the intensive blood pressure control group and propensity score-matched patients from the standard blood pressure control group across the achieved systolic blood pressure strata in the SPRINT trial

From: Clinical benefit of systolic blood pressure within the target range among patients with or without diabetes mellitus: a propensity score-matched analysis of two randomized clinical trials

 

Intention to treat

SBP < 110 mmHg

110 ≤ SBP < 120 mmHg

120 ≤ SBP < 130 mmHg

SBP ≥ 130 mmHg

Intensive (n = 4579)

Standard (n = 4579)

Intensive (n = 152)

Standard (n = 152)

Intensive (n = 2071)

Standard (n = 2071)

Intensive (n = 1619)

Standard (n = 1619)

Intensive (n = 636)

Standard (n = 636)

Demographics

 Age, years

67.88 ± 9.37

67.84 ± 9.43

64.84 ± 9.52

65.53 ± 8.83

66.47 ± 8.89

66.42 ± 9.16

68.70 ± 9.21

68.97 ± 9.32

71.43 ± 9.90

71.95 ± 9.92

 Female

1643 (35.88)

1603 (34.99)

58 (38.16)

62 (40.79)

733 (35.39)

762 (36.79)

562 (34.71)

553 (34.16)

261 (41.04)

247 (38.84)

 Race

  Black

1346 (29.40)

1389 (30.32)

49 (32.24)

56 (36.84)

570 (27.52)

560 (27.04)

480 (29.65)

461 (28.47)

215 (33.81)

201 (31.60)

  White

2645 (57.76)

2649 (57.83)

76 (50.00)

65 (42.76)

1186 (57.32)

1213 (58.57)

968 (59.79)

968 (59.79)

353 (55.50)

370 (58.18)

  Hispanic

493 (10.77)

473 (10.32)

25 (16.45)

28 (18.42)

527 (12.72)

256 (12.36)

143 (8.83)

158 (9.76)

48 (7.55)

43 (6.76)

  Others

95 (2.07)

70 (1.53)

2 (1.34)

3 (1.97)

85 (2.05)

42 (2.03)

28 (1.73)

32 (1.98)

20 (3.14)

22 (3.46)

Medical history

 Clinical CVD

755 (16.49)

758 (16.55)

30 (19.45)

30 (19.45)

316 (15.26)

289 (13.95)

272 (16.80)

293 (18.10)

120 (18.87)

120 (18.87)

 CKD

1293 (28.24)

1287 (28.09)

35 (23.03)

32 (21.05)

504 (24.34)

487 (23.52)

474 (29.28)

470 (29.03)

260 (40.88)

243 (38.21)

 Dyslipidemia

1941 (42.39)

2034 (44.40)

72 (47.37)

78 (51.32)

884 (42.68)

891 (43.02)

667 (41.20)

669 (41.32)

278 (43.71)

289 (45.44)

 Hypertension treatment

4160 (90.85)

4143 (90.44)

140 (92.11)

145 (95.39)

1853 (89.47)

1861 (89.86)

1473 (90.98)

1483 (91.60)

603 (94.81)

600 (94.34)

 Aspirin treatment

2361 (51.65)

2304 (50.69)

68 (44.74)

64 (42.11)

1056 (50.99)

1047 (50.56)

883 (54.54)

939 (58.00)

313 (49.21)

310 (48.74)

 Current smoking

629 (13.74)

590 (12.90)

35 (23.03)

43 (28.29)

284 (13.71)

270 (13.04)

199 (12.29)

198 (12.23)

87 (13.68)

95 (14.94)

 Current drinking

1632 (35.77)

1607 (35.20)

55 (36.18)

46 (30.29)

733 (35.39)

753 (36.36)

561 (34.65)

537 (33.17)

253 (39.78)

257 (40.41)

Biometric and laboratory data

 10-year risk for CVD, %

24.78 ± 12.59

24.78 ± 12.44

21.25 ± 11.45

22.42 ± 11.81

22.91 ± 11.76

22.74 ± 11.66

25.73 ± 12.42

25.70 ± 12.17

28.38 ± 13.96

29.96 ± 13.20

 BMI, kg/m2

29.87 ± 5.68

29.74 ± 5.59

31.90 ± 6.31

32.03 ± 7.23

30.38 ± 5.64

30.40 ± 5.57

29.50 ± 5.53

29.60 ± 5.50

28.52 ± 5.49

28.52 ± 5.53

 SBP, mmHg

139.60 ± 15.74

139.63 ± 15.38

132.63 ± 17.71

134.01 ± 13.31

136.85 ± 14.48

136.88 ± 14.66

141.28 ± 15.67

140.25 ± 15.59

146.33 ± 16.44

146.84 ± 16.60

 DBP, mmHg

78.24 ± 11.89

78.07 ± 11.93

78.78 ± 12.81

78.69 ± 11.14

78.80 ± 11.05

78.84 ± 11.75

77.90 ± 12.26

77.40 ± 11.77

76.94 ± 13.09

76.62 ± 12.24

 BLU, mmol/L

6.67 ± 2.40

6.72 ± 2.39

6.48 ± 2.22

6.43 ± 1.91

6.48 ± 2.22

6.49 ± 2.11

6.69 ± 2.35

6.70 ± 2.41

7.29 ± 3.00

7.13 ± 2.91

 Chloride, mmol/L

102.92 ± 2.90

102.93 ± 2.84

103.19 ± 3.21

103.11 ± 2.66

103.12 ± 2.73

103.07 ± 2.85

102.72 ± 2.93

102.75 ± 2.96

102.80 ± 3.20

102.99 ± 2.84

 Creatinine, μmmol/L

94.74 ± 30.38

95.17 ± 29.69

90.25 ± 27.45

89.58 ± 27.71

91.67 ± 26.91

91.05 ± 25.81

95.90 ± 30.94

95.30 ± 30.74

102.58 ± 36.99

100.51 ± 34.76

 Heart rate

66.18 ± 11.49

66.26 ± 11.59

66.60 ± 11.75

67.62 ± 11.34

66.71 ± 11.36

66.97 ± 11.47

65.81 ± 11.53

66.15 ± 11.25

64.66 ± 11.10

67.49 ± 21.99

 eGFR, mL/min/1.73 m2

71.90 ± 20.68

71.69 ± 20.44

76.88 ± 23.75

76.94 ± 22.42

74.01 ± 20.14

74.00 ± 19.92

70.83 ± 19.99

71.21 ± 20.23

66.15 ± 21.46

67.49 ± 21.99

 Glucose, mmol/L

5.54 ± 0.77

5.53 ± 0.75

5.49 ± 0.68

5.42 ± 0.70

5.56 ± 0.77

5.61 ± 0.87

5.53 ± 0.77

5.55 ± 0.80

5.50 ± 0.78

5.51 ± 0.76

 HDL-C, mmol/L

1.37 ± 0.37

1.37 ± 0.38

1.33 ± 0.35

1.34 ± 0.33

1.34 ± 0.34

1.34 ± 0.35

1.39 ± 0.39

1.38 ± 0.39

1.44 ± 0.40

1.41 ± 0.35

 LDL-C, mmol/L

2.91 ± 0.92

2.90 ± 0.90

2.93 ± 0.89

2.89 ± 0.92

2.91 ± 0.91

2.93 ± 0.93

2.92 ± 0.93

2.91 ± 0.90

2.87 ± 0.92

2.92 ± 0.93

 Potassium, mmol/L

4.21 ± 0.44

4.20 ± 0.45

4.19 ± 0.54

4.20 ± 0.72

4.19 ± 0.42

4.18 ± 0.43

4.21 ± 0.42

4.21 ± 0.48

4.23 ± 0.48

4.22 ± 0.45

 Sodium, mmol/L

140.12 ± 2.46

140.15 ± 2.42

140.14 ± 2.53

140.32 ± 2.20

140.31 ± 2.25

140.26 ± 2.43

139.99 ± 2.57

139.95 ± 2.53

139.95 ± 2.75

140.17 ± 2.43

 TC, mmol/L

4.92 ± 1.07

4.91 ± 1.06

4.88 ± 1.05

4.81 ± 1.07

4.89 ± 1.05

4.91 ± 1.06

4.94 ± 1.07

4.91 ± 1.05

4.89 ± 1.05

4.93 ± 1.10

 Triglycerides, mmol/L

1.37 ± 0.95

1.40 ± 1.04

1.29 ± 0.55

1.23 ± 0.61

1.36 ± 0.68

1.37 ± 0.71

1.32 ± 0.68

1.33 ± 0.69

1.23 ± 0.61

1.27 ± 0.66

Post-baseline characteristics

 Achieved SBP, mmHg

121.72 ± 8.78

135.51 ± 7.45

107.05 ± 2.65

134.20 ± 8.42

116.09 ± 2.54

134.95 ± 7.41

123.89 ± 2.72

136.07 ± 7.19

137.42 ± 8.37

138.09 ± 8.20

 Achieved DBP, mmHg

67.98 ± 8.43

75.11 ± 9.17

64.42 ± 7.70

77.65 ± 9.25

67.01 ± 7.08

76.25 ± 8.89

68.14 ± 8.42

74.65 ± 8.97

71.84 ± 9.86

71.48 ± 11.18

  1. Categorical variables are reported as the percentage with the characteristic. Continuous variables are reported as mean ± SD
  2. Baseline covariables listed in the table are included in the logistic model to calculate the propensity score of each patient from the SPRINT trial
  3. BLU blood urea nitrogen, BMI body mass index, CKD chronic kidney disease, CVD cardiovascular disease, DBP diastolic blood pressure, eGFR estimated glomerular filtration rate, HLD-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, SBP systolic blood pressure, TC total cholesterol