Table 2 Characteristics of patients in the intensive blood pressure control group and propensity score-matched patients from the standard blood pressure control group across the achieved systolic blood pressure strata in the ACCORD trial
Intention to treat | SBP < 110 mmHg | 110 ≤ SBP < 120 mmHg | 120 ≤ SBP < 130 mmHg | SBP ≥ 130 mmHg | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
Intensive (n = 2359) | Standard (n = 2368) | Intensive (n = 173) | Standard (n = 173) | Intensive (n = 1169) | Standard (n = 1169) | Intensive (n = 676) | Standard (n = 676) | Intensive (n = 310) | Standard (n = 310) | |
Demographics | ||||||||||
Age, years | 62.72 ± 6.60 | 62.75 ± 6.76 | 62.15 ± 6.81 | 61.28 ± 6.06 | 62.03 ± 6.50 | 62.25 ± 6.63 | 63.03 ± 6.56 | 63.56 ± 6.90 | 64.98 ± 6.47 | 65.01 ± 6.55 |
Female | 1127 (47.77) | 1129 (47.68) | 104 (60.12) | 107 (61.85) | 552 (47.22) | 519 (44.40) | 316 (46.75) | 291 (43.05) | 171 (55.16) | 169 (54.52) |
Race | ||||||||||
Black | 546 (23.15) | 577 (24.37) | 28 (16.18) | 40 (723.12) | 214 (18.31) | 224 (19.16) | 176 (26.04) | 182 (26.92) | 121 (39.03) | 124 (40.00) |
White | 1411 (59.81) | 1368 (57.77) | 127 (73.41) | 125 (70.62) | 741 (63.39) | 731 (62.53) | 374 (55.33) | 386 (57.10) | 136 (43.87) | 132 (42.58) |
Hispanic | 160 (6.78) | 170 (7.18) | 5 (2.89) | 3 (1.73) | 78 (6.67) | 75 (6.42) | 51 (7.54) | 48 (7.10) | 28 (9.03) | 32 (10.32) |
Others | 242 (10.26) | 253 (10.68) | 13 (7.51) | 9 (5.20) | 136 (11.63) | 139 (11.89) | 66 (9.76) | 69 (10.21) | 22 (7.10) | 25 (8.06) |
Randomized glycemic treatment | 1177 (49.89) | 1193 (50.38) | 93 (53.76) | 85 (49.13) | 573 (49.02) | 563 (48.16) | 341 (50.44) | 335 (49.56) | 163 (52.58) | 162 (52.26) |
Medical history | ||||||||||
Clinical CVD | 803 (34.04) | 788 (33.28) | 65 (37.57) | 68 (39.31) | 379 (32.42) | 372 (31.82) | 224 (33.14) | 235 (34.76) | 118 (38.06) | 120 (38.71) |
Clinical heart disease | 658 (27.89) | 657 (27.74) | 61 (35.26) | 57 (32.95) | 327 (28.31) | 331 (28.31) | 181 (26.78) | 199 (29.44) | 78 (25.16) | 85 (27.42) |
Dyslipidemia | 1629 (69.06) | 1670 (70.52) | 129 (74.57) | 122 (70.52) | 833 (71.26) | 835 (71.43) | 443 (65.53) | 427 (63.17) | 203 (65.48) | 206 (66.45) |
Hypertension treatment | 2082 (88.26) | 2068 (87.33) | 153 (88.44) | 152 (87.86) | 1011 (86.48) | 996 (85.20) | 607 (89.79) | 616 (91.12) | 281 (90.65) | 281 (90.65) |
Dyslipidemia treatment | 1906 (80.80) | 1892 (79.90) | 144 (83.24) | 149 (86.13) | 977 (82.87) | 969 (82.89) | 537 (79.44) | 532 (78.70) | 233 (75.16) | 241 (77.74) |
Current smoking | 971 (41.16) | 977 (41.26) | 76 (43.93) | 71 (41.04) | 502 (42.94) | 500 (42.77) | 276 (40.83) | 294 (43.49) | 104 (33.55) | 96 (30.97) |
Current drinking | 561 (23.78) | 544 (22.97) | 33 (19.08) | 39 (22.54) | 285 (24.38) | 283 (24.21) | 169 (25.00) | 196 (28.99) | 67 (21.61) | 73 (23.55) |
Biometric and laboratory data | ||||||||||
BMI, kg/m2 | 32.19 ± 5.60 | 32.10 ± 5.38 | 32.62 ± 5.40 | 32.50 ± 5.37 | 32.07 ± 5.54 | 32.31 ± 5.49 | 32.29 ± 5.66 | 31.59 ± 5.16 | 31.97 ± 5.78 | 32.26 ± 5.56 |
SBP, mmHg | 139.02 ± 16.12 | 139.34 ± 15.54 | 129.53 ± 15.18 | 129.79 ± 13.50 | 136.08 ± 14.28 | 135.52 ± 14.37 | 141.69 ± 16.53 | 141.53 ± 16.36 | 149.74 ± 15.77 | 149.79 ± 17.05 |
DBP, mmHg | 75.93 ± 10.56 | 75.98 ± 10.23 | 73.88 ± 10.14 | 75.00 ± 9.48 | 75.65 ± 9.74 | 75.07 ± 9.85 | 76.43 ± 11.56 | 76.65 ± 10.67 | 77.16 ± 11.55 | 77.21 ± 10.31 |
Waist, cm | 106.02 ± 14.08 | 105.36 ± 13.26 | 106.71 ± 14.24 | 106.09 ± 12.62 | 105.97 ± 13.96 | 106.28 ± 12.94 | 106.45 ± 13.96 | 105.39 ± 13.15 | 104.79 ± 14.42 | 105.33 ± 13.73 |
Creatinine, μmmol/L | 79.22 ± 21.05 | 79.22 ± 20.85 | 74.76 ± 19.34 | 74.71 ± 18.42 | 77.43 ± 20.50 | 76.13 ± 19.05 | 80.93 ± 20.49 | 82.29 ± 21.15 | 85.23 ± 23.43 | 87.03 ± 22.48 |
CPK, mg/dL | 137.45 ± 119.35 | 146.51 ± 145.12 | 120.78 ± 111.22 | 117.60 ± 74.95 | 132.10 ± 101.81 | 132.92 ± 109.03 | 149.17 ± 138.98 | 142.97 ± 114.91 | 143.60 ± 139.06 | 155.22 ± 132.46 |
eGFR, mL/min/1.73 m2 | 91.57 ± 30.30 | 91.63 ± 27.13 | 91.96 ± 26.83 | 92.17 ± 22.47 | 93.84 ± 25.89 | 95.16 ± 29.29 | 89.88 ± 38.07 | 89.41 ± 28.74 | 85.34 ± 26.10 | 84.49 ± 28.84 |
Glucose, mmol/L | 9.86 ± 3.23 | 9.70 ± 3.23 | 9.35 ± 2.79 | 9.23 ± 2.35 | 9.75 ± 3.10 | 9.64 ± 3.10 | 10.08 ± 3.32 | 10.04 ± 3.48 | 10.00 ± 3.71 | 10.11 ± 3.44 |
HDL-C, mmol/L | 1.19 ± 0.34 | 1.20 ± 0.36 | 1.20 ± 0.35 | 1.20 ± 0.34 | 1.19 ± 0.33 | 1.19 ± 0.36 | 1.19 ± 0.36 | 1.22 ± 0.39 | 1.20 ± 0.33 | 1.22 ± 0.34 |
LDL-C, mmol/L | 2.87 ± 0.97 | 2.81 ± 0.93 | 2.93 ± 1.04 | 3.00 ± 0.95 | 2.83 ± 0.96 | 2.78 ± 0.99 | 2.87 ± 0.94 | 2.84 ± 0.96 | 3.03 ± 0.99 | 2.88 ± 0.92 |
Potassium, mmol/L | 4.47 ± 0.47 | 4.47 ± 0.57 | 4.48 ± 0.40 | 4.44 ± 0.43 | 4.46 ± 0.47 | 4.46 ± 0.44 | 4.49 ± 0.45 | 4.52 ± 0.49 | 4.48 ± 0.50 | 4.43 ± 0.47 |
TC, mmol/L | 5.02 ± 1.17 | 4.95 ± 1.15 | 5.06 ± 1.17 | 5.08 ± 1.09 | 4.97 ± 1.17 | 4.94 ± 1.25 | 5.03 ± 1.12 | 4.99 ± 1.14 | 5.13 ± 1.17 | 4.93 ± 1.04 |
Triglycerides, mmol/L | 2.14 ± 1.96 | 2.10 ± 2.03 | 2.03 ± 1.45 | 1.96 ± 1.27 | 2.14 ± 1.93 | 2.21 ± 2.66 | 2.21 ± 1.96 | 2.13 ± 2.13 | 2.02 ± 1.75 | 1.84 ± 1.40 |
Post-baseline characteristics | ||||||||||
Achieved SBP, mmHg | 120.43 ± 9.66 | 133.83 ± 9.40 | 107.04 ± 3.10 | 131.70 ± 9.20 | 115.49 ± 2.57 | 132.54 ± 8.66 | 124.04 ± 2.82 | 134.02 ± 10.13 | 138.95 ± 9.55 | 136.36 ± 10.20 |
Achieved DBP, mmHg | 65.39 ± 7.48 | 71.31 ± 8.01 | 61.85 ± 5.74 | 72.07 ± 7.53 | 64.74 ± 6.69 | 71.28 ± 7.71 | 65.82 ± 7.53 | 70.49 ± 8.78 | 68.91 ± 9.49 | 70.14 ± 8.80 |