Fig. 2

Single-cell-type expression of the potentially lacunar stroke-risk genes. Bar graph of single-cell-type enrichment for risk genes in lacunar stroke from the discovery PWAS. The diagram depicts CELL-type EXpression-specificity (y axis) for each gene (x axis), with evidence of substantial enrichment within a specific brain cell type (histogram of the bar). We used the “wisdom of the crowd” technique to assess enrichment based on gene expression in one cell type against all other cell types. OPC, oligodendrocyte precursor cell. None: Cell types that cannot be classified