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Table 1 The discovery lacunar stroke PWAS identified 7 significant genes, of which 5 were found in the confirmation PWAS, and all 4 replicated

From: Identification of novel proteins for lacunar stroke by integrating genome-wide association data and human brain proteomes

   

Discovery PWAS

Confirmation PWAS

Evidence for replication

 

Gene

Chromosome

PWAS z-score

PWAS P

PWAS FDR P

PWAS z-score

PWAS P

1

CAND2

3

−4.281

1.86E−05

1.36E−02

−4.334

1.46E−05

Yes

2

ICA1L

2

−5.136

2.81E−07

4.11E−04

−4.213

2.52E−05

Yes

3

ALDH2

12

3.871

1.09E−04

3.98E−02

3.567

3.61E−04

Yes

4

MADD

11

3.770

1.63E−04

3.98E−02

2.917

3.53E−03

Yes

5

MRVI1

11

−3.776

1.60E−04

3.98E−02

−1.680

9.30E−02

-

6

CSPG4a

15

3.696

2.19E−04

4.58E−02

-

-

 

7

PTPN11a

12

−3.884

1.03E−04

3.98E−02

-

-

 
  1. This table gives the z-scores for the lacunar stroke PWAS associations with their corresponding P values and FDR-adjusted P values for all significant genes in the lacunar stroke discovery PWAS. Confirmation lacunar stroke PWAS z-scores and their corresponding unadjusted P values are provided for the significant genes in the discovery lacunar stroke PWAS
  2. aProtein not profiled in the confirmation proteomic dataset