Elevated levels of body mass index and waist circumference, but not high variability, are associated with an increased risk of atrial fibrillation

Table 2 Associations of average BMI and WC with risk of atrial fibrillation

	Event/Total	Incidence rate (per 1000 persons-years)	Multivariable-adjusted HR (95% CI)^a	HR (95% CI) in model using time-dependent variables^b
Average BMI categories
Underweight	3/523	0.60	0.77 (0.25, 2.44)	1.18 (0.55, 2.53)
Normal weight	132/17,107	0.80	1.00 (reference)	1.00 (reference)
Overweight	177/19,187	0.95	1.15 (0.90, 1.46)	1.28 (1.02, 1.62)
Obesity	98/7318	1.39	1.73 (1.31, 2.30)	1.89 (1.45, 2.46)
Continuous (per kg/m²)			1.06 (1.03, 1.10)	1.07 (1.04, 1.10)
Average WC categories
Abdominal obesity (−)	182/24222	0.76	1.00 (reference)	1.00 (reference)
Abdominal obesity (+)	228/19913	1.21	1.38 (1.11, 1.60)	1.46 (1.17, 1.78)
Continuous (per cm)			1.02 (1.01, 1.03)	1.02 (1.01, 1.03)

Abbreviations: BMI Body mass index, CI Confidence interval, HR Hazard ratio, WC Waist circumference
^aModels were adjusted for age, sex, physical activity, smoking status, alcohol drinking status, low-density lipoprotein cholesterol, heart rate, hypertension, and diabetes
^bThe models with BMI/WC, physical activity, smoking status, alcohol drinking status, low-density lipoprotein cholesterol, heart rate, hypertension, and diabetes as time-dependent variables and age and sex as time-fixed variables

ISSN: 1741-7015