Endpoint | Number of metrics for ideal cardiovascular health, HR (95% CI) | P-trend1 | |||
---|---|---|---|---|---|
0–2 (n = 767) | 3 (n = 1062) | 4 (n = 948) | 5–7 (n = 1049) | ||
Major cardiovascular diseasea | |||||
Events/person-years | 53/9126 | 83/12594 | 46/11482 | 12/13156 | |
Incidence rate/10,000 person years | 58.07 | 65.90 | 40.06 | 9.12 | |
Unadjusted model | 1.00 (ref.) | 1.14 (0.81–1.61) | 0.69 (0.46–1.02) | 0.16 (0.08–0.29) | < 0.001 |
Sex- and age-adjusted model | 1.00 (ref.) | 1.12 (0.79–1.58) | 0.78 (0.52–1.16) | 0.31 (0.16–0.58) | < 0.001 |
MV-adjusted modelb | 1.00 (ref.) | 1.12 (0.79–1.59) | 0.79 (0.53–1.18) | 0.32 (0.17–0.60) | < 0.001 |
Rate advancement periods (years) | |||||
MV-adjusted modelb | 0.00 (ref.) | 1.44 (− 2.92, 5.80) | − 2.94 (− 7.94, 2.06) | − 14.36 (− 22.85, − 5.87) | |
Myocardial infarction | |||||
Events/person-years | 20/9213 | 31/12739 | 11/11579 | 5/13175 | |
Incidence rate/10,000 person years | 21.71 | 24.33 | 9.50 | 3.80 | |
Unadjusted model | 1.00 (ref.) | 1.12 (0.64–1.97) | 0.44 (0.21–0.91) | 0.18 (0.07–0.47) | < 0.001 |
Sex- and age-adjusted model | 1.00 (ref.) | 1.18 (0.67–2.08) | 0.52 (0.25–1.09) | 0.31 (0.11–0.84) | 0.004 |
MV-adjusted modelb | 1.00 (ref.) | 1.18 (0.67–2.08) | 0.53 (0.25–1.10) | 0.32 (0.12–0.87) | 0.006 |
Rate advancement periods (years) | |||||
MV-adjusted modelb | 0.00 (ref.) | 3.74 (− 9.24, 16.73) | − 14.49 (− 32.66, 3.67) | − 27.79 (− 54.93, − 1.34) | |
Stroke | |||||
Events/person-years | 23/9216 | 39/12751 | 20/11545 | 5/13184 | |
Incidence rate/10,000 person years | 24.96. | 30.59 | 17.32 | 37.92 | |
Unadjusted model | 1.00 (ref.) | 1.23 (0.73–2.06) | 0.69 (0.38–1.26) | 0.15 (0.06–0.40) | < 0.001 |
Sex- and age-adjusted model | 1.00 (ref.) | 1.17 (0.69–1.96) | 0.77 (0.42–1.40) | 0.30 (0.11–0.80) | 0.011 |
MV-adjusted modelb | 1.00 (ref.) | 1.15 (0.69–1.94) | 0.76 (0.41–1.39) | 0.29 (0.11–0.77) | 0.009 |
Rate advancement periods (years) | |||||
MV-adjusted modelb | 0.00 (ref.) | 1.47 (− 3.92, 6.86) | − 2.87 (− 9.13, 3.39) | − 12.77 (− 23.44, − 2.10) | |
Death from cardiovascular causes | |||||
Events/person-years | 17/9313 | 27/12907 | 20/11642 | 2/13204 | |
Incidence rate/10,000 person years | 18.26 | 20.92 | 17.18 | 1.51 | |
Unadjusted model | 1.00 (ref.) | 1.15 (0.63–2.11) | 0.94 (0.49–1.79) | 0.08 (0.02–0.36) | < 0.001 |
Sex- and age-adjusted model | 1.00 (ref.) | 1.03 (0.56–1.90) | 1.02 (0.53–1.95) | 0.18 (0.04–0.77) | 0.059 |
MV-adjusted modelb | 1.00 (ref.) | 1.04 (0.57–1.92) | 1.03 (0.54–1.97) | 0.19 (0.04–0.80) | 0.072 |
Rate advancement periods (years) | |||||
MV-adjusted modelb | 0.00 (ref.) | 0.34 (− 4.63, 5.31) | 0.25 (− 5.05, 5.55) | − 13.77 (− 26.23, − 1.,31) | |
Expanded composite major cardiovascular diseasec | |||||
Events/person-years | 94/8868 | 112/12409 | 64/11372 | 22/13084 | |
Incidence rate/10,000 person years | 106.00 | 90.25 | 56.28 | 16.81 | |
Unadjusted model | 1.00 (ref.) | 0.85 (0.65–1.12) | 0.53 (0.39–0.73) | 0.16 (0.10–0.25) | < 0.001 |
Sex- and age-adjusted model | 1.00 (ref.) | 0.85 (0.64–1.12) | 0.61 (0.44–0.84) | 0.30 (0.19–0.49) | < 0.001 |
MV-adjusted modelb | 1.00 (ref.) | 0.85 (0.65–1.12) | 0.61 (0.44–0.84) | 0.31 (0.19–0.49) | < 0.001 |
Rate advancement periods (years) | |||||
MV-adjusted modelb | 0.00 (ref.) | − 2.33 (− 6.36, 1.69) | − 7.16 (− 11.94, − 2.37) | − 17.22 (− 24.84, − 9.59) |