Fig. 4

Unique spatial distribution of immune cell subtypes in CLDN18.2-positive GC. A Illustration of the spatial analysis involving tumor cell and immune cell. Red dots and green dots represent tumor cells and immune cells, respectively. White line connecting a red dot and a green dot means that the distance between two cells are less than 20 microns. ES: effective score. EP: effective percent. Comparison of the effective scores (B) and effective percent (C) between the CLDN18.2-positive group and CLDN18.2-negative group (central cells: tumor cells; peripheral cells: immune cells; radius range: 20 microns). Red points and lines: CLDN18.2-positive; blue points and lines: CLDN18.2-negative