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Table 2 Baseline characteristics of the total cohort and cases with or without IDC-P

From: Homologous recombination deficiency (HRD) score in aggressive prostatic adenocarcinoma with or without intraductal carcinoma of the prostate (IDC-P)

  

All patients (N=123)

Without IDC-P (N=46)

With IDC-P (N=77)

P value

HRD score (median [IQR])

 

21.0 [11.0, 28.5]

14.0 [6.2, 24.8]

23.0 [14.0, 30.0]

0.002

 HRD score (%)

<21

58 (47.15)

28 (60.87)

30 (38.96)

0.019

≥21

65 (52.85)

18 (39.13)

47 (61.04)

 

 Metastasis (%)

No

45 (36.59)

18 (39.13)

27 (35.06)

0.795

Yes

78 (63.41)

28 (60.87)

50 (64.94)

 

 Visceral metastasis (%)

No

119 (96.75)

44 (95.65)

75 (97.40)

0.997

Yes

4 (3.25)

2 (4.35)

2 (2.60)

 

 IDCP pattern (%)

0

46 (37.40)

46 (100.00)

0 (0.00)

<0.001

1

19 (15.45)

0 (0.00)

19 (24.68)

 

2

58 (47.15)

0 (0.00)

58 (75.32)

 

 ISUP/WHO (%)

1-3

20 (16.26)

10 (21.74)

10 (12.99)

0.308

4-5

103 (83.74)

36 (78.26)

67 (87.01)

 

Age (median [IQR])

 

69.0 [64.0, 73.5]

69.5 [67.0, 75.0]

68.0 [62.0, 73.0]

0.235

 Age (%)

<70

67 (54.47)

23 (50.00)

44 (57.14)

0.56

≥70

56 (45.53)

23 (50.00)

33 (42.86)

 

PSA (median [IQR])

 

67.8 [19.6, 100.1]

75.1 [28.7, 100.1]

60.0 [15.3, 100.1]

0.187

 Baseline PSA (ng/mL, %)

<100

72 (58.54)

26 (56.52)

46 (59.74)

0.872

≥100

51 (41.46)

20 (43.48)

31 (40.26)

 
  1. HRD homologous recombination deficiency, IDC-P intraductal carcinoma of the prostate, ISUP International Society of Urological Pathology, PSA prostate-specific antigen, IQR interquartile range