Table 2 BMI, HOMA-IR, and AUCglucose [mean and 95% CI] and estimated mean differences within the per-protocol analysis. Intervention effects are reported as estimated marginal means and estimated mean differences [intervention minus control] based on a mixed-model, repeated-measures analysis of variance adjusted for the treatment group, sex, age, and BMI at baseline
Months after weight loss | Intervention group [kg/m2] | Control group [kg/m2] | Group difference |
|---|---|---|---|
BMI [kg/m2] | |||
0 | 31.46 [31.11, 31.81] | 31.84 [31.48, 32.20] | -0.39 [-0.84, 0.07] |
12 | 31.71 [31.00, 32.44]** | 33.05 [32.29, 33.82] | -1.35 [-2.39, -0.31] |
18 | 33.04 [32.30, 33.79] | 33.79 [33.01, 34.56] | -0.74 [-1.80, 0.31] |
24 | 33.47 [32.69, 34.25] | 34.09 [33.28, 34.91] | -0.63 [-1.74, 0.48] |
36 | 33.90 [33.15, 34.65] | 34.42 [33.60, 35.25] | -0.52 [-1.61, 0.57] |
48 | 34.21 [33.39, 35.03] | 34.72 [33.78, 35.66] | -0.51 [-1.74, 0.72] |
HOMA-IR | |||
0 | 1.44 [1.22, 1.67] | 1.68 [1.44, 1.91] | -0.24 [-0.53, 0.06] |
12 | 1.60 [1.32, 1.87]* | 2.07 [1.77, 2.37] | -0.47 [-0.86, -0.09] |
18 | 2.05 [1.67, 2.42] | 2.43 [2.03, 2.84] | -0.39 [-0.93, 0.16] |
24 | 1.98 [1.62, 2.35] | 2.36 [1.97, 2.75] | -0.37 [-0.90, 0.15] |
36 | 2.57 [2.01, 3.13] | 2.77 [2.11, 3.43] | -0.20 [-1.05, 0.65] |
48 | 2.52 [1.91, 3.14] | 3.45 [2.71, 4.19] | -0.93 [-1.88, 0.03] |
AUCglucose [mg dl−1 min−1] | |||
0 | 270 [256, 285] | 271 [256, 286] | -0.92 [-20.10, 18.26] |
12 | 275 [257, 292]* | 300 [282 –318] | -25.65 [-49.32, -1.99] |
18 | 293 [277, 309] | 305 [289, 322] | -12.65 [-34.36, 9.05] |
24 | 297 [277, 318] | 325 [304, 347] | -27.77 [-56.09, 0.56] |
36 | 315 [294, 335] | 343 [320, 365] | -27.68 [-56.54, 1.18] |
48 | 327 [305, 348] | 344 [320, 368] | -17.85 [-48.78, 13.08] |