Fig. 2

Association between genetically predicted IL-6R-mediated signaling activity and risk of cardiovascular disease across clinically relevant subgroups. The hazard ratios are scaled on 1 mg/dL increment in absolute hsCRP levels. The p-values for heterogeneity and for trend are derived from the Cochran Q statistic and linear meta-regression analyses across strata of the different measured variables. For all variables except for age and sex, the residual values are used to stratify, as determined in models regressing the genetic score for IL-6 signaling on these variables