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Table 2 Net reclassification improvement of adding 24 metabolites into a conventional risk prediction model

From: Plasma metabolomic profiles of dementia: a prospective study of 110,655 participants in the UK Biobank

  Conventional prediction model Updated model
Incident dementia in 10 years Risk (%) <5 >5
Yes <5 668 48
>5 6 76
No <5 101,185 654
>5 353 823
  1. Values are n. Patients in the upper-right cell were rightfully up-reclassified (n=48, and 6 patients were mistakenly down-reclassified), indicating an improved sensitivity. Patients in the lower-left cell were rightfully down-reclassified (n=353, and 654 patients mistakenly up-reclassified), indicating an undermined specificity. NRI (SE) = 0.0497 (0.00921), P value <0.001·