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Table 2 Net reclassification improvement of adding 24 metabolites into a conventional risk prediction model

From: Plasma metabolomic profiles of dementia: a prospective study of 110,655 participants in the UK Biobank

 

Conventional prediction model

Updated model

Incident dementia in 10 years

Risk (%)

<5

>5

Yes

<5

668

48

>5

6

76

No

<5

101,185

654

>5

353

823

  1. Values are n. Patients in the upper-right cell were rightfully up-reclassified (n=48, and 6 patients were mistakenly down-reclassified), indicating an improved sensitivity. Patients in the lower-left cell were rightfully down-reclassified (n=353, and 654 patients mistakenly up-reclassified), indicating an undermined specificity. NRI (SE) = 0.0497 (0.00921), P value <0.001·
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BMC Medicine

ISSN: 1741-7015

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