Medium- and longer-term cardiovascular effects of e-cigarettes in adults making a stop-smoking attempt: a randomized controlled trial

Table 5 Change of secondary outcome variables over baseline

Variables—change over baseline	Nicotine replacement therapy (NRT)				Nicotine-containing e-cigarettes				Nicotine-free e-cigarettes
	Mean difference	95% CI		p value	Mean difference	95% CI		p value	Mean difference	95% CI		p value
	Mean difference	Lower	Upper	p value	Mean difference	Lower	Upper	p value	Mean difference	Lower	Upper	p value
CO (reduction in parts per million)
3 months over baseline	10	8	11	< .001	9	7	11	< .001	7	5	9	< .001
6 months over baseline	8	6	10	< .001	9	7	11	< .001	6	4	8	< .001
TC/HDL ratio (reduction)
3 months over baseline	0.89	− 0.16	1.91	0.09	0.18	− 0.02	0.39	0.08	0.11	− 0.14	0.36	0.39
6 months over baseline	0.78	− 0.27	1.80	0.15	0.23	0.06	0.40	0.009	0.01	− 0.23	0.24	0.97
QRISK (reduction in %)
3 months over baseline	1.8	0.9	2.7	< .001	1.6	0.6	2.6	0.002	2.1	1.2	3.0	< .001
6 months over baseline	0.9	− 0.4	2.3	0.164	1.8	0.8	2.7	< .001	1.7	0.7	2.7	0.001

ISSN: 1741-7015