Skip to main content
Fig. 2 | BMC Medicine

Fig. 2

From: Cardiovascular health in the menopause transition: a longitudinal study of up to 3892 women with up to four repeated measures of risk factors

Fig. 2

Associations of reproductive and chronological aging with carotid intima media thickness. The left-hand panel shows the main analysis results: mean difference in carotid intima media thickness (CIMT) per year for reproductive and chronological age with mutual adjustment for each age variable and pre-pregnancy body mass index (BMI), age at menarche, parity, maternal education, smoking status and alcohol intake, undertaken in 1627 women with 2561 observations. The right-hand panel shows the additional analyses undertaken to explore possible selection bias in the main analysis. The figure shows the mean difference in CIMT per year in chronological age by menopausal stage (pre, peri or post), undertaken in all eligible women (total N = 3765 women with 5628 observations, with 2238 (2652), 1209 (1254) and 1344 (1722) women (observations) contributing data to pre, peri and post-menopause, respectively). Each trajectory was restricted to the middle 95% of the data, except for the youngest ages in the premenopausal group and the oldest ages in the postmenopausal group. The 5th and 95th percentile of chronological age in pre, peri and post-menopausal stage are 40–52, 47–55, and 49–61, respectively. The p-value for interaction, a test for any difference in the linear association between any of the three menopause stages, is reported in Table S6 (and by age in Table S7)

Back to article page