Fig. 4

Biochemical metabolic analysis. A Metabolic set enrichment analysis showing altered lipid signatures analyzed by SMPDB metabolite set library. B, C Significantly altered lipid metabolite box plots allocated to related pathways. Patients were stratified regarding ISUP group. Statistic comparation was performed between high-risk (groups III, IV, and V) and low-risk (group I). Each box shows the median, quartiles, and extreme values. *p < 0.05, **p < 0.01