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Table 2 Risk of IBS according to Quartiles of baseline fatty liver index

From: Non-alcoholic fatty liver is associated with increased risk of irritable bowel syndrome: a prospective cohort study

  Quartile 1 Quartile 2 Quartile 3 Quartile 4 P for trend
No. of participants 98,371 99,289 99,714 99,464  
No. of incident IBS 1882 1797 1701 1749  
Follow-up, person-years 1,192,803 1,197,965 1,199,435 1,185,959  
Follow-up, years
 Mean ± SD 12.1 ± 1.8 12.1 ± 1.8 12.0 ± 1.9 11.9 ± 2.1  
 Median (IQR) 12.4 (11.7–13.1) 12.4 (11.6–13.1) 12.4 (11.6–13.1) 12.3 (11.6–13.1)  
Hazard ratio for incident IBS (95%CI, P value)
 Adjusted model 1 Reference 1.15 (1.08–1.23) 1.24 (1.16–1.33) 1.36 (1.27–1.46)  < 0.001
 Adjusted model 2 Reference 1.13 (1.06–1.21) 1.20 (1.12–1.28) 1.27 (1.19–1.37)  < 0.001
 Adjusted model 3 Reference 1.12 (1.05–1.20) 1.17 (1.10–1.26) 1.21 (1.13–1.30)  < 0.001
  1. Note: Adjusted model 1: Age and gender were adjusted; Adjusted model 2: Townsend deprivation index, education level, ethnicity, smoking status, and alcohol drinking were additionally adjusted; Adjusted model 3: IPAQ (International Physical Activity Questionnaire), and type 2 diabetes were additionally adjusted; P for trend was calculated by using median value (10.5, 32.2, 61.2, and 88.6) of each fatty liver index quartile
  2. IBS irritable bowel syndrome, SD standard deviation, IQR inter-quartile range