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Table 2 Risk of IBS according to Quartiles of baseline fatty liver index

From: Non-alcoholic fatty liver is associated with increased risk of irritable bowel syndrome: a prospective cohort study

 

Quartile 1

Quartile 2

Quartile 3

Quartile 4

P for trend

No. of participants

98,371

99,289

99,714

99,464

 

No. of incident IBS

1882

1797

1701

1749

 

Follow-up, person-years

1,192,803

1,197,965

1,199,435

1,185,959

 

Follow-up, years

 Mean ± SD

12.1 ± 1.8

12.1 ± 1.8

12.0 ± 1.9

11.9 ± 2.1

 

 Median (IQR)

12.4 (11.7–13.1)

12.4 (11.6–13.1)

12.4 (11.6–13.1)

12.3 (11.6–13.1)

 

Hazard ratio for incident IBS (95%CI, P value)

 Adjusted model 1

Reference

1.15 (1.08–1.23)

1.24 (1.16–1.33)

1.36 (1.27–1.46)

 < 0.001

 Adjusted model 2

Reference

1.13 (1.06–1.21)

1.20 (1.12–1.28)

1.27 (1.19–1.37)

 < 0.001

 Adjusted model 3

Reference

1.12 (1.05–1.20)

1.17 (1.10–1.26)

1.21 (1.13–1.30)

 < 0.001

  1. Note: Adjusted model 1: Age and gender were adjusted; Adjusted model 2: Townsend deprivation index, education level, ethnicity, smoking status, and alcohol drinking were additionally adjusted; Adjusted model 3: IPAQ (International Physical Activity Questionnaire), and type 2 diabetes were additionally adjusted; P for trend was calculated by using median value (10.5, 32.2, 61.2, and 88.6) of each fatty liver index quartile
  2. IBS irritable bowel syndrome, SD standard deviation, IQR inter-quartile range