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Table 3 Inverse probability weighting-adjusted Cox regression of biological and radiological responses to induction chemotherapy in 821 patients with locally advanced nasopharynx of head and neck cancer

From: Improving on-treatment risk stratification of cancer patients with refined response classification and integration of circulating tumor DNA kinetics

Covariates Subgroup DFS OS DMFS LRFS
HR 95%CI P HR 95%CI P HR 95%CI P HR 95%CI P
Post-NAC cfEBV DNAa cBR vs. Non-cBR 2.81 2.16–3.66 <0.01 2.34 1.68–3.26 <0.01 3.45 2.43–4.91 <0.01 1.89 1.27–2.82 <0.01
Post-NAC MRIa CR vs. PR 2.34 1.05–5.25 0.04 2.21 0.74–6.62 0.16 1.79 0.68–4.70 0.24 2.70 0.86–8.43 0.09
CR vs. SD/PD 4.98 2.15–11.55 <0.01 5.24 1.69–16.31 <0.01 3.30 1.20–9.13 0.02 5.57 1.74–17.85 <0.01
Response Phenotypesa G1: cBR+CR (References) 1.00 1.00 1.00 1.00
G3: cBR+PR 1.52 0.69–3.33 0.30 1.52 0.54–4.34 0.43 1.03 0.40–2.63 0.95 1.93 0.61–6.09 0.26
G4: non-cBR+PR 4.44 2.01–9.84 <0.01 3.56 1.23–10.29 0.02 3.91 1.52–10.02 <0.01 4.02 1.25–12.95 0.02
G5: cBR+SD/PD 2.81 1.14–6.95 0.03 2.51 0.77–8.24 0.13 0.80 0.21–3.12 0.75 5.03 1.40–18.01 0.01
G6: non-cBR+SD/PD 6.60 2.85–15.29 <0.01 7.18 2.391.61 <0.01 5.09 1.90–13.63 <0.01 5.04 1.48–17.11 0.01
  1. Abbreviations: cBR Complete biological response, cfEBV DNA Cell-free Epstein-Barr virus DNA, CI Confidence interval, CR Complete response, DFS Disease-free survival, DMFS Distant metastasis-free survival, HR Hazard ratio, LRFS Locoregional relapse-free survival, MRI Magnetic resonance imaging, NAC Neoadjuvant chemotherapy, non-cBR Non-complete biological response, OS Overall survival, PD Progression disease, PR Partial responses, SD Stable disease
  2. aThe following variables were adjusted via IPW algorithm: age (<45 vs. ≥45 years), sex (male vs. female), smoking (No vs. Yes), alcohol (No vs. Yes), pretreatment EBV DNA (<2 vs. ≥2 × 103 copies/mL), T stage (T1-2 vs. T3-4), N stage (N0-1 vs. N2-3), IC regimens (TPF vs. GP vs. TP vs. PF vs. others), IC cycles (2 cycles vs. 3 cycles vs. 4 cycles), CCD (<160 vs. ≥160 mg/m2). Two-sided P-values were calculated using the chi-square test