Fig. 1

RTS,S vaccine-induced antibodies interact with FcγRs. Serum samples from children in the RTS,S vaccine group from Manhiça (blue box plots, n=50) and Ilha Josina (orange box plots, n=49) study sites were tested for antibodies that bind FcγRIIa (left panels; A, C, E) and FcγRIII (right panels; B, D, F). Samples collected at baseline (month 0, M0) and after the third vaccination (month 3, M3) were tested against A, B full-length CSP, C, D central-repeat (NANP) and E, F C-terminal (CT) regions of CSP. Boxes represent the interquartile range (IQR) with median (bar), and whiskers represent the highest and lowest values within 1.5× IQR. Values in the Y-axis indicate the optical density (OD) at 450nm. The percentage of children with a positive response are shown in Additional file 1: Figure S1, and reactivities between paired samples were compared using Wilcoxon’s signed rank sum test