Fig. 4

Correlations between antibody response types among children vaccinated with RTS,S. Serum samples from children vaccinated with RTS,S from the Manhiça and Ilha Josina study sites at M3 were tested for FcγRIIa/III-binding to CSP and serum samples from children in the Manhiça cohort were also tested for opsonic phagocytosis and ADRB with neutrophils. Individual samples are shown as the following scatter plots: A anti-CSP IgG and FcγRIIa or FcγRIII-binding (n=100); B FcγRIIa and FcγRIII binding by study site (Manhiça, n=50 and Ilha Josina, n=49); C FcγRIIa and FcγRIII binding to CSP by age group (younger, n=35 and older, n=65); D FcγRIIa or FcγRIII-binding and opsonic phagocytosis by neutrophils; and E FcγRIIa or FcγRIII binding and ADRB. Correlations were evaluated using Spearman’s correlation coefficient (r). P-values <0.001 for all correlations. FcγR binding data are reported as optical density (OD) at 450nm