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Table 1 Decay rate of RTS,S-induced antibodies at different time points during follow-up

From: Induction, decay, and determinants of functional antibodies following vaccination with the RTS,S malaria vaccine in young children

  Follow-up time intervals
Antibody parameter M3–M8.5 M8.5–M21 M21–M33 M33–M45 M45–M63
FcγRIIa-binding 19% 10% 8% 5% 5%
FcγRIII-binding 25% 9% 6% 5% 5%
Neutrophil phagocytosis 4% 4% 3% 2% *0%
Neutrophil ADRB 28% *4% 9% *−2% *−2%
THP-1 cell phagocytosis 4% 4% 4% *0% *0%
IgG1 11% 3% 3% *1% *1%
IgG2 13% 9% 9% *−8% *0%
IgG3 22% 4% 4% 4% *−4%
IgG4 *−22% *−6% *9% *8% *5%
  1. Changes in RTS,S-induced antibodies are reported as decay rate − percentage reduction in magnitude per month for each time interval
  2. See Table S2 in Additional file 1: Materials for further details
  3. *The p-value for all decay rates is <0.05, except where indicated with an asterisk