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Table 1 Decay rate of RTS,S-induced antibodies at different time points during follow-up

From: Induction, decay, and determinants of functional antibodies following vaccination with the RTS,S malaria vaccine in young children

 

Follow-up time intervals

Antibody parameter

M3–M8.5

M8.5–M21

M21–M33

M33–M45

M45–M63

FcγRIIa-binding

19%

10%

8%

5%

5%

FcγRIII-binding

25%

9%

6%

5%

5%

Neutrophil phagocytosis

4%

4%

3%

2%

*0%

Neutrophil ADRB

28%

*4%

9%

*−2%

*−2%

THP-1 cell phagocytosis

4%

4%

4%

*0%

*0%

IgG1

11%

3%

3%

*1%

*1%

IgG2

13%

9%

9%

*−8%

*0%

IgG3

22%

4%

4%

4%

*−4%

IgG4

*−22%

*−6%

*9%

*8%

*5%

  1. Changes in RTS,S-induced antibodies are reported as decay rate − percentage reduction in magnitude per month for each time interval
  2. See Table S2 in Additional file 1: Materials for further details
  3. *The p-value for all decay rates is <0.05, except where indicated with an asterisk