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Table 2 Diagnostic performance of candidate emRNAs for distinguishing localized clear cell renal cell carcinoma (ccRCC) patients from healthy controls in the training and validation sets

From: Circulating exosomal mRNA signatures for the early diagnosis of clear cell renal cell carcinoma

mRNA group Training set Validation set
Univariate Multivariate Univariate Multivariate
p Youden index AUC p p Youden index AUC p
CUL9 0.0266 0.27 0.611 / / / / /
KMT2D 0.0002 0.35 0.668 0.0011  < 0.0001 0.29 0.655 0.0013
PBRM1 0.0029 0.30 0.639 / / / / /
PREX2  < 0.0001 0.62 0.742  < 0.0001  < 0.0001 0.61 0.776  < 0.0001
SETD2 0.0007 0.41 0.680 / / / / /
  1. Note. AUC of ccRCC diagnostic signature for ccRCC versus healthy = 0.836 (95% CI, 0.765 to 0.893). Logistic regression model (method of stepwise) = 1.21943 × KMT2D + 1.97072 × PREX2 + 1.30485. ccRCC, clear cell renal cell carcinoma; ROC, receiver operator characteristic; AUC, area under the curve