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Table 2 Diagnostic performance of candidate emRNAs for distinguishing localized clear cell renal cell carcinoma (ccRCC) patients from healthy controls in the training and validation sets

From: Circulating exosomal mRNA signatures for the early diagnosis of clear cell renal cell carcinoma

mRNA group

Training set

Validation set

Univariate

Multivariate

Univariate

Multivariate

p

Youden index

AUC

p

p

Youden index

AUC

p

CUL9

0.0266

0.27

0.611

/

/

/

/

/

KMT2D

0.0002

0.35

0.668

0.0011

 < 0.0001

0.29

0.655

0.0013

PBRM1

0.0029

0.30

0.639

/

/

/

/

/

PREX2

 < 0.0001

0.62

0.742

 < 0.0001

 < 0.0001

0.61

0.776

 < 0.0001

SETD2

0.0007

0.41

0.680

/

/

/

/

/

  1. Note. AUC of ccRCC diagnostic signature for ccRCC versus healthy = 0.836 (95% CI, 0.765 to 0.893). Logistic regression model (method of stepwise) = 1.21943 × KMT2D + 1.97072 × PREX2 + 1.30485. ccRCC, clear cell renal cell carcinoma; ROC, receiver operator characteristic; AUC, area under the curve
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BMC Medicine

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