Skip to main content

Table 3 Diagnostic performance of candidate emRNAs for distinguishing localized clear cell renal cell carcinoma (ccRCC) patients from patients with benign renal masses

From: Circulating exosomal mRNA signatures for the early diagnosis of clear cell renal cell carcinoma

mRNA group ccRCC vs benign ccRCC vs benign (solid) ccRCC vs benign (cystic)
Univariate Multivariate Multivariate Multivariate
p Youden index AUC p p p
CUL9 0.0039 0.23 0.619  < 0.0001 0.0005 0.0095
KMT2D 0.0504 0.25 0.585  < 0.0001 0.0010 0.0003
PBRM1 0.5989 0.16 0.524 / / /
PREX2 0.0022 0.24 0.629 0.0001 0.0003 0.0048
SETD2 0.6855 0.07 0.518 / / /
  1. Note. AUC of ccRCC diagnostic signature for ccRCC versus benign = 0.816 (95% CI, 0.751 to 0.870). Logistic regression model (method of stepwise) = 1.68689 × CUL9 − 1.16173 × KMT2D + 1.17881 × PREX2 + 0.75145. ccRCC, clear cell renal cell carcinoma; ROC, receiver operator characteristic; AUC, area under the curve