Circulating exosomal mRNA signatures for the early diagnosis of clear cell renal cell carcinoma

Table 3 Diagnostic performance of candidate emRNAs for distinguishing localized clear cell renal cell carcinoma (ccRCC) patients from patients with benign renal masses

mRNA group	ccRCC vs benign				ccRCC vs benign (solid)	ccRCC vs benign (cystic)
	Univariate			Multivariate	Multivariate	Multivariate
	p	Youden index	AUC	p	p	p
CUL9	0.0039	0.23	0.619	< 0.0001	0.0005	0.0095
KMT2D	0.0504	0.25	0.585	< 0.0001	0.0010	0.0003
PBRM1	0.5989	0.16	0.524	/	/	/
PREX2	0.0022	0.24	0.629	0.0001	0.0003	0.0048
SETD2	0.6855	0.07	0.518	/	/	/

Note. AUC of ccRCC diagnostic signature for ccRCC versus benign = 0.816 (95% CI, 0.751 to 0.870). Logistic regression model (method of stepwise) = 1.68689 × CUL9 − 1.16173 × KMT2D + 1.17881 × PREX2 + 0.75145. ccRCC, clear cell renal cell carcinoma; ROC, receiver operator characteristic; AUC, area under the curve

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