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Table 3 Risk of secondary obstetric outcomes among women with PCOS compared to women without PCOS

From: Polycystic ovary syndrome and risk of adverse obstetric outcomes: a retrospective population-based matched cohort study in England

Outcomes

Deliveries of women with PCOS*

Age-matched deliveries of women without PCOS

Very preterm (< 32 weeks of gestational age at delivery)

  Number of patients

27,586

110,344

  Outcome events, n(%)

619 (2.24%)

2244 (2.03%)

  Unadjusted OR (95% CI)

1.11 (1.01–1.22)

  Adjusted OR (95% CI) (Model 1)

1.09 (0.99–1.19)

  Adjusted OR (95% CI) (Model 2)

1.07 (0.97–1.18)

  Adjusted OR (95% CI) (Model 3)

1.07 (0.97–1.18)

  Adjusted OR (95% CI) (Model 4)

1.07 (0.97–1.18)

Extremely preterm (< 28 weeks of gestational age at delivery)

  Number of patients

27,586

110,344

  Outcome events, n (%)

272 (0.99%)

909 (0.82%)

  Unadjusted OR (95% CI)

1.20 (1.04–1.39)

  Adjusted OR (95% CI) (Model 1)

1.16 (1.01–1.33)

  Adjusted OR (95% CI) (Model 2)

1.14 (0.99–1.31)

  Adjusted OR (95% CI) (Model 3)

1.13 (0.98–1.29)

  Adjusted OR (95% CI) (Model 4)

1.13 (0.98–1.29)

Large for gestational age > 90th percentile (for at least one of the babies)

  Number of patients

27,586

110,344

  Outcome events, n (%)

4922 (17.84%)

18,593 (16.85%)

  Unadjusted OR (95% CI)

1.07 (1.03–1.11)

  Adjusted OR (95% CI) (Model 1)

1.08 (1.05–1.12)

  Adjusted OR (95% CI) (Model 2)

1.06 (1.03–1.10)

  Adjusted OR (95% CI) (Model 3)

1.06 (1.03–1.10)

  Adjusted OR (95% CI) (Model 4)

1.00 (0.97–1.04)

Small for gestational age < 10th percentile (for at least one of the babies)

  Number of patients

27,586

110,344

  Outcome events, n (%)

1113 (4.03%)

4305 (3.90%)

  Unadjusted OR (95% CI)

1.04 (0.97–1.11)

  Adjusted OR (95% CI) (Model 1)

1.01 (0.94–1.09)

  Adjusted OR (95% CI) (Model 2)

1.01 (0.94–1.09)

  Adjusted OR (95% CI) (Model 3)

1.00 (0.93–1.08)

  Adjusted OR (95% CI) (Model 4)

1.03 (0.96–1.11)

  1. *Record of PCOS/PCO/combination of symptom codes indicating a missed PCOS diagnosis based on Rotterdam criteria [(1) anovulation and (2) biochemical or symptomatic presentation of hyperandrogenism; Read code record of hair loss or hirsutism and a recorded measure of serum testosterone level ≥ 2.0 nmol/L was considered as symptomatic and biochemical presentation of hyperandrogenism, respectively]
  2. PCOS Polycystic ovary syndrome, CS Caesarean section, OR Odds ratio
  3. Model 1: Adjusted for age, ethnicity, and deprivation
  4. Model 2: Adjusted for age, ethnicity, deprivation, baseline dysglycaemia, hypertension and thyroid disorders
  5. Model 3: Adjusted for age, ethnicity, deprivation, baseline dysglycaemia, hypertension, thyroid disorders, and numbers of babies born at the delivery
  6. Model 4: Adjusted for age, ethnicity, deprivation, baseline dysglycaemia, hypertension, thyroid disorders, numbers of babies born at the delivery, and pre-gravid body mass index
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BMC Medicine

ISSN: 1741-7015

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