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Table 3 All-cause mortality by frailty phenotype in individuals with and without mental disorders

From: Frailty in individuals with depression, bipolar disorder and anxiety disorders: longitudinal analyses of all-cause mortality

  Model 1 RD % Model 2 RD %
HR 95% CI pBonf. pBH HR 95% CI pBonf. pBH
Depression
 Non-frail No Ref Ref
 Non-frail Yes 1.042 0.986 1.101 >0.999 0.158 1.016 0.960 1.074 >0.999 0.590
 Pre-frail No 1.352 1.305 1.400 <0.001 <0.001 1.233 1.190 1.278 <0.001 <0.001
 Pre-frail Yes 1.457 1.387 1.530 <0.001 <0.001 29.95 1.263 1.200 1.329 <0.001 <0.001 12.91
 Frail No 2.864 2.630 3.118 <0.001 <0.001 1.968 1.803 2.149 <0.001 <0.001
 Frail Yes 3.289 2.990 3.619 <0.001 <0.001 22.83 2.104 1.905 2.325 <0.001 <0.001 14.02
Bipolar disorder
 Non-frail No Ref Ref
 Non-frail Yes 1.602 1.276 2.011 0.002 <0.001 1.359 1.082 1.707 0.253 0.010
 Pre-frail No 1.352 1.305 1.400 <0.001 <0.001 1.232 1.188 1.276 <0.001 <0.001
 Pre-frail Yes 2.144 1.784 2.576 <0.001 <0.001 225.04 1.681 1.397 2.022 <0.001 <0.001 193.89
 Frail No 2.864 2.631 3.118 <0.001 <0.001 1.959 1.792 2.142 <0.001 <0.001
 Frail Yes 3.647 2.400 5.543 <0.001 <0.001 42.01 2.296 1.508 3.495 0.003 <0.001 35.06
Anxiety disorder
 Non-frail No Ref Ref
 Non-frail Yes 0.976 0.907 1.049 >0.999 0.520 0.972 0.903 1.046 >0.999 0.478
 Pre-frail No 1.352 1.305 1.400 <0.001 <0.001 1.232 1.189 1.276 <0.001 <0.001
 Pre-frail Yes 1.212 1.132 1.298 <0.001 <0.001 − 39.79 1.089 1.016 1.169 0.493 0.019 − 61.39
 Frail No 2.864 2.631 3.118 <0.001 <0.001 1.958 1.792 2.139 <0.001 <0.001
 Frail Yes 3.031 2.625 3.500 <0.001 <0.001 8.97 2.041 1.762 2.364 <0.001 <0.001 8.69
  1. HR hazard ratio, CI confidence interval, RD % percentage risk difference, Ref reference group, Bonf. Bonferroni, BH Benjamini and Hochberg. Age (in years) was used as the underlying time axis. Model 1—unadjusted; Model 2—adjusted for sex, ethnicity, highest qualification, Townsend deprivation index, cohabitation with spouse/partner, smoking status, alcohol intake frequency, systolic and diastolic blood pressure, body mass index, cholesterol, multimorbidity count and assessment centre