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Table 4 All-cause mortality by frailty index categories in individuals with and without mental disorders

From: Frailty in individuals with depression, bipolar disorder and anxiety disorders: longitudinal analyses of all-cause mortality

  Model 1 Model 2
HR 95% CI pBonf. pBH RD % HR 95% CI pBonf. pBH RD %
Depression
 Non-frail No Ref Ref
 Non-frail Yes 1.050 0.954 1.157 >0.999 0.354 1.081 0.981 1.191 >0.999 0.137
 Pre-frail No 1.390 1.336 1.446 <0.001 <0.001 1.168 1.118 1.221 <0.001 <0.001
 Pre-frail Yes 1.372 1.305 1.443 <0.001 <0.001 − 4.64 1.174 1.111 1.241 <0.001 <0.001 3.53
 Frail No 2.564 2.393 2.746 <0.001 <0.001 1.622 1.498 1.755 <0.001 <0.001
 Frail Yes 2.555 2.380 2.744 <0.001 <0.001 − 0.55 1.606 1.479 1.744 <0.001 <0.001 − 2.48
Bipolar disorder
 Non-frail No Ref Ref
 Non-frail Yes 1.297 0.805 2.089 >0.999 0.329 1.214 0.754 1.956 >0.999 0.455
 Pre-frail No 1.389 1.335 1.445 <0.001 <0.001 1.164 1.113 1.218 <0.001 <0.001
 Pre-frail Yes 2.034 1.715 2.411 <0.001 <0.001 165.90 1.540 1.296 1.831 <0.001 <0.001 229.15
 Frail No 2.559 2.389 2.742 <0.001 <0.001 1.604 1.478 1.742 <0.001 <0.001
 Frail Yes 3.714 2.865 4.814 <0.001 <0.001 74.02 2.220 1.704 2.891 <0.001 <0.001 101.77
Anxiety disorder
 Non-frail No Ref Ref
 Non-frail Yes 1.002 0.877 1.144 >0.999 0.981 1.043 0.913 1.191 >0.999 0.552
 Pre-frail No 1.389 1.335 1.445 <0.001 <0.001 1.169 1.118 1.222 <0.001 <0.001
 Pre-frail Yes 1.198 1.124 1.277 <0.001 <0.001 − 49.13 1.063 0.993 1.138 >0.999 0.109 − 62.95
 Frail No 2.561 2.390 2.744 <0.001 <0.001 1.604 1.480 1.739 <0.001 <0.001
 Frail Yes 2.107 1.905 2.331 <0.001 <0.001 − 29.06 1.403 1.258 1.566 <0.001 <0.001 − 33.27
  1. HR hazard ratio, CI confidence interval, RD % percentage risk difference, Ref reference group, Bonf. Bonferroni, BH Benjamini and Hochberg. Age (in years) was used as the underlying time axis. Model 1—unadjusted; Model 2—adjusted for sex, ethnicity, highest qualification, Townsend deprivation index, cohabitation with spouse/partner, smoking status, alcohol intake frequency, systolic and diastolic blood pressure, body mass index, cholesterol, multimorbidity count and assessment centre