Populations: all participants aged 50 years and over with multimorbidity (two conditions or more)
Studies focused solely on toxicity reactions
Interventions (concepts/process and theory)—any systematic intervention process used to safely withdraw medications in older people with multimorbidity and polypharmacy and the outcomes used to measure the effectiveness of these strategies.
Context: documents conducted in any appropriate setting (general practice/pharmacy/home setting)
Documents from low- and middle-income countries, studies not published in English
Study design: Any comparative studies including RCTs, cohort or case control studies, qualitative studies and grey literature