Fig. 3

Genes significantly associated with type 2 diabetes (T2D), peripheral artery disease (PAD), or cross-trait shared architecture of T2D and PAD identified by MAGMA or SMR analysis in Europeans and East Asians. A The genes significantly associated with T2D, PAD, or cross-trait shared architecture of T2D and PAD identified by multi-marker analysis of genomic annotation (MAGMA) in Europeans and East Asians, and the genes associated with T2D, PAD, or cross-trait shared architecture of T2D and PAD identified by summary data-based Mendelian randomization (SMR) in B Europeans and C East Asians. The color bar in A represents the z-score in MAGMA analysis. The width of the line in B and C denotes the strength of the SMR association. In B and C, lines in purple and orange represent respectively up- and downregulated genes associated with the increasing risk of the disease in question