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Table 1 Genetic correlation between T2D and PAD in Europeans and East Asians

From: Genetic evidence for a causal relationship between type 2 diabetes and peripheral artery disease in both Europeans and East Asians

    Constrained intercept Unconstrained intercept
T2D PAD T2D PAD
EUR Single-trait LDSC h2 ± SE 28.08% ± 1.35% 12.23% ± 1.40% 23.47% ± 1.47% 10.93% ± 1.86%
Ph2 2.29 × 10−85 3.11 × 10−17 9.42 × 10−52 8.54 × 10−9
Cross-trait LDSC rg ± SE 0.44 ± 0.05 0.51 ± 0.07
Prg 5.23 × 10−17 9.34 × 10−15
EAS Single-trait LDSC h2 ± SE 21.48% ± 1.17% 13.58% ± 2.04% 15.12% ± 1.37% 18.83% ± 2.93%
Ph2 2.45 × 10−67 8.34 × 10−11 3.61 × 10−26 3.44 × 10−10
Cross-trait LDSC rg ± SE 0.45 ± 0.07 0.46 ± 0.06
Prg 1.16 × 10−10 1.67 × 10−12
  1. PAD peripheral artery disease, T2D type 2 diabetes, h2 heritability, rg genetic correlation, SE standard error, Ph2p-value for estimated h2, Prgp-value for estimated rg, LDSC linkage disequilibrium score regression, EUR Europeans, EAS East Asians