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Table 1 Genetic correlation between T2D and PAD in Europeans and East Asians

From: Genetic evidence for a causal relationship between type 2 diabetes and peripheral artery disease in both Europeans and East Asians

   

Constrained intercept

Unconstrained intercept

T2D

PAD

T2D

PAD

EUR

Single-trait LDSC

h2 ± SE

28.08% ± 1.35%

12.23% ± 1.40%

23.47% ± 1.47%

10.93% ± 1.86%

Ph2

2.29 × 10−85

3.11 × 10−17

9.42 × 10−52

8.54 × 10−9

Cross-trait LDSC

rg ± SE

0.44 ± 0.05

0.51 ± 0.07

Prg

5.23 × 10−17

9.34 × 10−15

EAS

Single-trait LDSC

h2 ± SE

21.48% ± 1.17%

13.58% ± 2.04%

15.12% ± 1.37%

18.83% ± 2.93%

Ph2

2.45 × 10−67

8.34 × 10−11

3.61 × 10−26

3.44 × 10−10

Cross-trait LDSC

rg ± SE

0.45 ± 0.07

0.46 ± 0.06

Prg

1.16 × 10−10

1.67 × 10−12

  1. PAD peripheral artery disease, T2D type 2 diabetes, h2 heritability, rg genetic correlation, SE standard error, Ph2p-value for estimated h2, Prgp-value for estimated rg, LDSC linkage disequilibrium score regression, EUR Europeans, EAS East Asians
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BMC Medicine

ISSN: 1741-7015

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