Patient characteristics | Sorafenib group (n=100) | Control group (n=102) | P value |
---|---|---|---|
Gender, male/female | 50 (50.0%)/50 (50.0%) | 52 (51.0%)/50 (49.0%) | 0.889 |
Patient age, median (range), years | 35 (18–60) | 35 (18–59) | 0.916 |
WBC at diagnosis, median (range) | 54.8 (1.3–463.0) | 74.8 (1.7–385.1) | 0.473 |
Cytogenetic risk# | Â | Â | 0.818 |
 Low risk | 6 (6.0%) | 4 (3.9%) |  |
 Intermediate risk | 80 (80.0%) | 85 (83.3%) |  |
 High risk | 7 (7.0%) | 5 (4.9%) |  |
 Unknown | 7 (7.0%) | 8 (7.8%) |  |
NPM1 mutation | Â | Â | 0.575 |
 Concomitant | 29 (29.0%) | 26 (25.5%) |  |
 Without | 71 (71.0%) | 76 (74.5%) |  |
EBV serostatus | Â | Â | 0.910 |
 D−/R- | 21 (21.0%) | 19 (18.6%) |  |
 D+/R- | 24 (24.0%) | 28 (27.5%) |  |
 D−/R+ | 20 (20.0%) | 22 (21.6%) |  |
 D+/R+ | 35 (35.0%) | 33 (32.3%) |  |
CMV serostatus | Â | Â | 0.982 |
 D−/R− | 7 (7.0%) | 7 (6.9%) |  |
 D+/R− | 5 (5.0%) | 4 (3.9%) |  |
 D−R+ | 9 (9.0%) | 10 (9.8%) |  |
 D+/R+ | 79 (79.0%) | 81 (79.4%) |  |
Sorafenib pre-transplant | Â | Â | 0.654 |
 Use | 59 (59.0%) | 57 (55.9%) |  |
 No use | 41 (41.0%) | 45 (44.1%) |  |
CR status at transplant | Â | Â | 0.546 |
 ≥ CR2 | 21 (21.0%) | 18 (17.6%) |  |
 CR1 | 79 (79.0%) | 84 (82.4%) |  |
MRD at transplant | Â | Â | 0.723 |
 Positive | 31 (31.0%) | 34 (33.3%) |  |
 Negative | 69 (69.0%) | 68 (66.7%) |  |
GVHD prophylaxis | Â | Â | 0.512 |
 CsA+MTX+MMF | 44 (44.0%) | 39 (38.2%) |  |
 CsA+MTX+ATG | 8 (8.0%) | 6 (5.9%) |  |
 CsA+MTX+ATG+MMF | 48 (48.0%) | 57 (55.9%) |  |
ATG use in the conditioning | Â | Â | 0.405 |
 Use | 44 (44.0%) | 39 (38.2%) |  |
 No use | 56 (56.0%) | 63 (61.8%) |  |
Transplant modality | Â | Â | 0.512 |
 MSD | 44 (44.0%) | 39 (38.2%) |  |
 MUD | 8 (8.0%) | 6 (5.9%) |  |
 HID | 48 (48.0%) | 57 (55.9%) |  |
Donor sources | Â | Â | 0.262 |
 PBSC | 52 (52.0%) | 45 (44.1%) |  |
 PBSC+BM | 48 (48.0%) | 57 (55.9%) |  |
Median CD34+cells per graft, 106/kg (range) | 6.3 (3.7–10.2) | 6.1 (3.3–11.3) | 0.746 |