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Table 1 Gene regions and corresponding positions used for different drug targets

From: Safety of beta-blocker and calcium channel blocker antihypertensive drugs in pregnancy: a Mendelian randomization study

Exposure drug target Gene Gene position (GRCh37/hg19) #SNPs (p < 5 × 10−8, r2 < 0.1) R2 F-statistic
Beta1-adrenoceptor blockers ADRB1 Chr10: 115,803,625–115,806,663 2 0.00028 105.49
Calcium channel blockers CACNA1C Chr3: 53,528,638–53,847,760 4 0.00029 55.09
CACNA1D ChrX: 49,061,523–49,089,802 0 - -
CACNA1F Chr7: 81,575,760–82,073,272 0 - -
CACNA1S Chr3: 50,400,044–50,541,675 0 - -
CACNA2D1 Chr1: 201,008,640–201,081,554 0 - -
CACNA2D2 Chr17: 37,329,706–37,353,922 0 - -
CACNB1 Chr10: 18,429,353–18,832,486 16 0.0015 72.81
CACNB2 Chr12: 49,208,263–49,222,724 1 9.28e × 10−05 70.28
CACNB3 Chr2: 152,689,285–152,955,681 0 - -
CACNB4 Chr17: 65,040,670–65,052,913 0 - -
CACNG1 Chr12: 2,162,153–2,807,116 2 0.0020 38.69
  1. F-statistic for systolic blood pressure is 62.77. Gene position obtained using DBSNP. Reported windows do not include ± 10kB window. F-statistic calculated using the formula \(F=\frac{(n-k-1)}{k} \frac{({R}^{2})}{(1-{R}^{2})}\), where we calculated \({R}^{2}\) by summing SNP-wise \({R}^{2}\) (using the formula \({R}^{2}= \frac{F}{(N-2+F)}\), with \(F={\left(\frac{\beta }{SE(\beta )}\right)}^{2}\)) to find joint \({R}^{2}\)
  2. Abbreviations: chr chromosome, “-” not available