Skip to main content

Table 3 Information on the studies and consortia from which genetic association data were obtained

From: Safety of beta-blocker and calcium channel blocker antihypertensive drugs in pregnancy: a Mendelian randomization study

Exposure

Phenotype name in study

Study

Ancestry

N cases (/controls)

Controls definition/selection criteria

Unit

PMID/link

Exposure data

Systolic blood pressure

Systolic blood pressure

Evangelou et al., 2018

European

757,601

-

mmHg

30,224,653

Outcome data

Pre-eclampsia or eclampsia

Pre-eclampsia or eclampsia

FINNGEN DF6

European

4743/136,325

Women without a hypertensive disorder in pregnancy

Log(OR) (yes vs no)

https://finngen.gitbook.io/documentation

Gestational diabetes

Diabetes mellitus in pregnancy

FINNGEN DF6

European

7676/130,424

Women without any pregnancy-related morbidity

Log(OR) (yes vs no)

https://finngen.gitbook.io/documentation

Birthweight of first child

First child birthweight

Neale Lab

European

155,202

Women who indicated they had given birth to at least one child (based on UKB data-field 2744)

Birthweight in pounds, split into three ordered categorical variable bins:

• 0 for < 7 pounds

• 1 for 7 pounds

• 2 for > 7 pounds

 http://www.nealelab.is/uk-biobank/