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Fig. 2 | BMC Medicine

Fig. 2

From: Dapagliflozin attenuates diabetes-induced diastolic dysfunction and cardiac fibrosis by regulating SGK1 signaling

Fig. 2

Dapagliflozin inhibits the expression of profibrotic proteins SGK1 and ENaC assessed by confocal immunofluorescence microscopy. A Comparison of SGK1 (green) expression in myocardial tissue. B Comparison of ENaC (green) expression in myocardial tissue. Relative area measurements were determined using a Zeiss LSM 700. Scale bar = 50μm. n = 3 each slide of 3 sections. C The direct effects of dapagliflozin on immunohistochemistry analysis of NHE1 in myocardial tissue (n = 10 per group). Scale bar = 200μm. D RT-PCR analyses of indicated genes in myocardial tissue (n = 10 per group). E Western blot analyses of indicated genes in myocardial tissue (n = 4 per group). Values are means ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001 compared to control group, p < 0.05, ††p < 0.01 compared to diabetes group

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