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Fig. 4 | BMC Medicine

Fig. 4

From: Dapagliflozin attenuates diabetes-induced diastolic dysfunction and cardiac fibrosis by regulating SGK1 signaling

Fig. 4

Dapagliflozin for suppression of fibrosis via SGK1, ENaC, and NHE1. A Representative RT-PCR bands of SGK1 in H9C2 transfected with SGK1 10-30 nM siRNA. B Representative Western blot bands of SGK1 in H9C2 transfected with SGK1 10-30 nM siRNA. Values are means ± SEM (n = 4). *p < 0.05, **p < 0.01, ***p < 0.001 compared to the siCon group. C RT-PCR analyses of indicated genes in H9C2. D Western blot analyses of indicated genes in H9C2. Values are means ± SEM (n = 6). *p < 0.05, **p < 0.01, ***p < 0.001 compared to the siCon group, p < 0.05, ††p < 0.01, †††p < 0.001 compared to palmitic acid + LPS siCon, p < 0.05 compared to palmitic acid + LPS siSGK + dapa, §p < 0.05, §§p < 0.01, §§§p < 0.001 compared to palmitic acid + LPS HG + siCon, p < 0.05 compared to palmitic acid + LPS HG + siSGK + dapa

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