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Fig. 5 | BMC Medicine

Fig. 5

From: Dapagliflozin attenuates diabetes-induced diastolic dysfunction and cardiac fibrosis by regulating SGK1 signaling

Fig. 5

Protective effect of dapagliflozin for mitochondrial cristae in myocardial tissue. Comparison of mitochondrion changes. A Transmission electron microscopy images of myocardial tissue treated with dapagliflozin. Scale bar = 5μm, 2μm, and 500nm from low to high magnification. B Immunohistochemistry analysis of Fis-1 and Mfn-1 expression and quantification of myocardial tissue cross-sectional area. Scale bar = 200μm. C RT-PCR analyses of indicated genes in myocardial tissue. D Western blot analyses of indicated genes in myocardial tissue (n = 4 per group). Values are means ± SEM (n = 10 per group). *p < 0.05, **p < 0.01, ***p < 0.001 compared to the Control group, p < 0.05 compared to the diabetes group

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