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Table 4 Sensitivity, specificity, and positive and negative predictive value for 10% and 25% of participants with the highest risk

From: External validation of models for predicting risk of colorectal cancer using the China Kadoorie Biobank

  Driver Ma Point Ma Cox Guo Chen Betes Aleksandrova Imperiale Hong
Top 10%
 Sensitivity 9.17 18.2 25.9 7.63 6.81 15.5 25.2 12.5 24.0
 Specificity 96.1 92.1 90.1 96.3 96.5 94.7 90.1 92.7 90.1
 PPV (%) 2.30 1.37 1.50 1.19 1.30 1.68 1.25 1.87 1.39
 NPV (%) 99.0 99.5 99.5 99.4 99.4 99.5 99.6 99.0 99.5
Top 25%
 Sensitivity (%) 36.8 38.7 52.7 40.1 38.7 35.5 51.8 32.7 48.7
 Specificity (%) 76.9 80.7 75.2 76.9 77.2 84.0 75.1 78.6 75.1
 PPV (%) 1.60 1.20 1.22 1.00 1.12 1.28 1.03 1.67 1.13
 NPV (%) 99.2 99.5 99.6 99.5 99.5 99.6 99.7 99.0 99.6