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Table 4 Sensitivity, specificity, and positive and negative predictive value for 10% and 25% of participants with the highest risk

From: External validation of models for predicting risk of colorectal cancer using the China Kadoorie Biobank

 

Driver

Ma Point

Ma Cox

Guo

Chen

Betes

Aleksandrova

Imperiale

Hong

Top 10%

 Sensitivity

9.17

18.2

25.9

7.63

6.81

15.5

25.2

12.5

24.0

 Specificity

96.1

92.1

90.1

96.3

96.5

94.7

90.1

92.7

90.1

 PPV (%)

2.30

1.37

1.50

1.19

1.30

1.68

1.25

1.87

1.39

 NPV (%)

99.0

99.5

99.5

99.4

99.4

99.5

99.6

99.0

99.5

Top 25%

 Sensitivity (%)

36.8

38.7

52.7

40.1

38.7

35.5

51.8

32.7

48.7

 Specificity (%)

76.9

80.7

75.2

76.9

77.2

84.0

75.1

78.6

75.1

 PPV (%)

1.60

1.20

1.22

1.00

1.12

1.28

1.03

1.67

1.13

 NPV (%)

99.2

99.5

99.6

99.5

99.5

99.6

99.7

99.0

99.6