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Fig. 2 | BMC Medicine

Fig. 2

From: Dissection of transcriptome dysregulation and immune characterization in women with germline BRCA1 mutation at single-cell resolution

Fig. 2

Tubal cellular populations and their differentially expressed genes. A Expression levels of a secretory marker, PAX8 (left panel), and a ciliated marker, TP73 (right panel). B tSNE plot shows the re-clustering result of all secretory and ciliated cells and the expression levels of their marker genes. C Volcano plot illustrating differential gene expressions between BRCA1 mutation carriers and normal controls in secretory cells (left panel), GSEA pathways enriched by differentially expressed genes (DEGs), the down-regulated pathways of cytokine-cytokine receptor interaction, and chemokine signaling pathway (right panel). D Volcano plot illustrating differential gene expression between BRCA1 mutation carriers and normal controls in ciliated cells (left panel), GSEA pathways enriched by differentially expressed genes, the down-regulated pathways of antigen processing and presentation and cell adhesion molecules cams (right panel). P values were estimated using the Benjamini-Hochberg procedure

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