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Table 1 OAI participant baseline characteristics

From: Single nucleotide polymorphism genes and mitochondrial DNA haplogroups as biomarkers for early prediction of knee osteoarthritis structural progressors: use of supervised machine learning classifiers

  Total (n = 901) Progressorsa (n = 276) No-progressorsa (n = 625) p-value
Age, years 61 ± 9 63 ± 9 60 ± 9 < 0.0001
Gender, man, % (n) 39 (347) 41 (114) 37 (233) 0.266b
BMI, kg/m2 28.3 ± 4.6 28.9 ± 4.8 28.0 ± 4.5 0.005
WOMAC
 Pain (0–20) 2.1 ± 2.9 2.7 ± 3.4 1.9 ± 2.6 0.0003
 Function (0–68) 6.8 ± 9.2 9.1 ± 11.1 5.8 ± 8.1 < 0.0001
 Stiffness (0–8) 1.5 ± 1.5 1.7 ± 1.7 1.4 ± 1.4 0.015
 Total (0–96) 10.4 ± 12.9 13.5 ± 15.6 9.0 ± 11.3 < 0.0001
Kellgren-Lawrence grade, % (n)     < 0.0001b
 0–1 53 (476) 26 (73) 64 (403)  
 2 34 (310) 41 (112) 32 (198)  
 3 10 (93) 28 (77) 3 (16)  
 4 2 (22) 5 (14) 1 (8)  
  (n = 796) (n = 268) (n = 528)  
Joint space width, mm 4.3 ± 1.3 3.2 ± 1.1 4.9 ± 1.0  < 0.0001
Joint space narrowing scorec 0.4 ± 0.6 1.1 ± 0.5 0.1 ± 0.2  < 0.0001
  1. BMI Body mass index, WOMAC Western Ontario and McMaster Universities Osteoarthritis Index, mm Medial minimum, n Number of participants
  2. aStructural progressors and no-progressors were as defined in the “Methods” section
  3. Continuous variables were compared using the Student’s t-test/Mann–Whitney test, and bproportions using the chi-squared test/Fisher’s exact test; p-values compared progressors from the no-progressors, and a p ≤ 0.050 (in bold) was considered statistically different
  4. cThe joint space narrowing (JSN) scoring at baseline was 0–2, as described in the OAI database [37]