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Fig. 2 | BMC Medicine

Fig. 2

From: A blood-based miRNA signature for early non-invasive diagnosis of preeclampsia

Fig. 2

Identification of differentially expressed miRNAs. A Volcano plot of the differential expression analysis comparing PE placental samples and normal placental samples. The log2FC is shown on the x-axis and the − log10(FDR-adjusted p-value) is shown on the y-axis. Each dot is a miRNA in the analysis. The red dots are significantly up-regulated miRNAs. The blue dots are significantly down-regulated miRNAs. B Unsupervised clustering based on the expression pattern of 5 DEmiRNAs. The columns represent samples, and the rows represent miRNAs. C Boxplots of the expression value of 5 DE miRNAs of the PE and normal samples in WMU cohort 1. Horizontal lines: median values. Statistical analysis was performed using the Wald test. p-value was adjusted using the FDR method. Metascape enrichment network visualization of enriched GO BP terms (D) and KEGG pathways (E) of up-regulated miRNA target genes. Metascape enrichment network visualization of enriched GO BP terms (F) and KEGG pathways (G) of down-regulated miRNA target genes. DEmiRNA, differentially expressed miRNA; FC, fold change; FDR, false discovery rate; GO, Gene Ontology; BP, biological processes; KEGG, Kyoto Encyclopedia of Genes and Genomes

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