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Table 1 Clinical characteristics of patients in four in-house cohorts

From: A blood-based miRNA signature for early non-invasive diagnosis of preeclampsia

Characteristics WMU cohort 1 WMU cohort 2 WMU cohort 3 WMU cohort 4
Healthy controls (n = 5) PE patients (n = 5) p-value Healthy controls (n = 20) PE patients (n = 20) p-value Healthy controls (n = 8) PE patients (n = 10) p-value Healthy controls (n = 18) PE patients (n = 19) p-value
Mean maternal age (years) 30.2 ± 5.7 31.0 ± 6.1 0.84 29.8 ± 5.1 30.4 ± 4.5 0.69 34.8 ± 4.2 31.1 ± 5.1 0.12 30.9 ± 4.8 31.3 ± 4.5 0.78
Mean BMI (kg/m2) 28.8 ± 2.9 30.6 ± 5.5 0.53 27.8 ± 1.9 28.0 ± 3.2 0.85 25.2 ± 2.5 27.6 ± 4.2 0.18 27.0 ± 2.7 27.8 ± 3.7 0.50
PreSBP (mmHg) 115.0 ± 7.0 164.6 ± 21.5  < 0.01 117.6 ± 10.8 146.4 ± 17.2  < 0.001 117.1 ± 10.1 152.9 ± 20.8  < 0.001 117.4 ± 9.8 150.8 ± 17.7  < 0.001
PreDBP (mmHg) 70.0 ± 6.3 107.2 ± 10.0  < 0.001 72.0 ± 8.7 96.0 ± 13.1  < 0.001 69.8 ± 5.3 100.6 ± 12.3  < 0.001 72.2 ± 6.5 100.4 ± 11.0  < 0.001
Mean ALB (g/L) 33.3 ± 3.2 29.8 ± 4.3 0.18 37.0 ± 3.4 30.4 ± 6.6  < 0.001 35.6 ± 3.1 31.3 ± 4.9  < 0.05 36.4 ± 2.8 32.5 ± 4.7  < 0.01
Mean ALT (IU/L) 10.2 ± 3.9 20.6 ± 11.1 0.08 10.5 ± 5.0 14.5 ± 7.3 0.05 9.6 ± 3.6 16.8 ± 12.7 0.14 10.2 ± 6.0 20.1 ± 11.6  < 0.001
Mean BUN (mmol/L) 2.9 ± 0.6 4.4 ± 1.9 0.15 3.0 ± 0.8 4.1 ± 1.5  < 0.01 3.1 ± 0.8 5.2 ± 2.9 0.07 3.0 ± 0.9 4.5 ± 2.2  < 0.05
BUN/CERA 0.07 ± 0.02 0.08 ± 0.03 0.40 0.07 ± 0.02 0.08 ± 0.02 0.12 0.08 ± 0.03 0.10 ± 0.04 0.39 0.07 ± 0.03 0.09 ± 0.03 0.14
Urine protein/urine CERA (mg/mmol) 12.3 ± 3.5 517.9 ± 203.1  < 0.001 11.9 ± 4.3 245.0 ± 307.6  < 0.001 9.7 ± 3.9 508.4 ± 405.9  < 0.001 11.2 ± 3.2 295.0 ± 327.0  < 0.001
Median GA delivery (week) 38.2 ± 1.1 35.6 ± 2.9 0.10 38.4 ± 0.9 35.7 ± 2.6  < 0.001 37.9 ± 0.6 32.9 ± 4.8  < 0.05 38.5 ± 0.9 34.0 ± 4.1  < 0.001
No. preterm deliveries (%) 0 (0.0%) 3 (60.0%) 0.17 0 (0.0%) 12 (60.0%)  < 0.001 0 (0.0%) 7 (70.0%)  < 0.01 0 (0.0%) 12 (63.2%)  < 0.001
Mean birthweight (g) 3376.0 ± 405.3 2244.0 ± 968.8  < 0.05 3412.0 ± 352.5 2461.0 ± 689.8  < 0.001 3358.0 ± 343.3 1795.0 ± 860.1  < 0.001 3443.0 ± 432.8 2138.0 ± 848.3  < 0.001
  1. Values are given as mean ± sd. or n(%)
  2. BMI Body mass index during pregnancy, PreSBP Preoperative systolic blood pressure, PreDBP Preoperative diastolic blood pressure, ALB Albumin, ALT Alanine transaminase, BUN Blood urea nitrogen, CREA Creatinine, GA Gestational age
  3. p values for comparisons between healthy controls with PE patients